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Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis
Blood-brain barrier (BBB) breakdown is a hallmark of many diseases of the central nervous system (CNS). Loss of BBB integrity in CNS diseases such as viral encephalitis results in the loss of nutrient/oxygen delivery, rapid infiltration of immune cells, and brain swelling that can exacerbate neurona...
Autores principales: | Bonney, Stephanie, Seitz, Scott, Ryan, Caitlin A., Jones, Kenneth L., Clarke, Penny, Tyler, Kenneth L., Siegenthaler, Julie A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686045/ https://www.ncbi.nlm.nih.gov/pubmed/31387911 http://dx.doi.org/10.1128/mBio.01675-19 |
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