Cargando…

Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED

BACKGROUND: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown. OBJECTIVE: The aim of this study was to examine the relation between...

Descripción completa

Detalles Bibliográficos
Autores principales: McCormick, Benjamin J J, Richard, Stephanie A, Caulfield, Laura E, Pendergast, Laura L, Seidman, Jessica C, Koshy, Beena, Roshan, Reeba, Shrestha, Rita, Svensen, Erling, Blacy, Ladislaus, Rasmussen, Zeba, Maphula, Angelina, Scharf, Rebecca, Nahar, Baitun, Haque, Sayma, Rasheed, Muneera, Oria, Reinaldo, Rogawski, Elizabeth T, Murray-Kolb, Laura E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686051/
https://www.ncbi.nlm.nih.gov/pubmed/31162601
http://dx.doi.org/10.1093/jn/nxz055
_version_ 1783442488914083840
author McCormick, Benjamin J J
Richard, Stephanie A
Caulfield, Laura E
Pendergast, Laura L
Seidman, Jessica C
Koshy, Beena
Roshan, Reeba
Shrestha, Rita
Svensen, Erling
Blacy, Ladislaus
Rasmussen, Zeba
Maphula, Angelina
Scharf, Rebecca
Nahar, Baitun
Haque, Sayma
Rasheed, Muneera
Oria, Reinaldo
Rogawski, Elizabeth T
Murray-Kolb, Laura E
author_facet McCormick, Benjamin J J
Richard, Stephanie A
Caulfield, Laura E
Pendergast, Laura L
Seidman, Jessica C
Koshy, Beena
Roshan, Reeba
Shrestha, Rita
Svensen, Erling
Blacy, Ladislaus
Rasmussen, Zeba
Maphula, Angelina
Scharf, Rebecca
Nahar, Baitun
Haque, Sayma
Rasheed, Muneera
Oria, Reinaldo
Rogawski, Elizabeth T
Murray-Kolb, Laura E
author_sort McCormick, Benjamin J J
collection PubMed
description BACKGROUND: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown. OBJECTIVE: The aim of this study was to examine the relation between early-life factors (birth to 2 y) and cognitive development at 5 y. METHODS: Observational follow-up visits were made of children at 5 y, previously enrolled in the community-based MAL-ED longitudinal cohort. The burden of enteropathogens, prevalence of illness, complementary diet intake, micronutrient status, and household and maternal factors from birth to 2 y were extensively measured and their relation with the Wechsler Preschool Primary Scales of Intelligence at 5 y was examined through use of linear regression. RESULTS: Cognitive T-scores from 813 of 1198 (68%) children were examined and 5 variables had significant associations in multivariable models: mean child plasma transferrin receptor concentration (β: −1.81, 95% CI: −2.75, −0.86), number of years of maternal education (β: 0.27, 95% CI: 0.08, 0.45), maternal cognitive reasoning score (β: 0.09, 95% CI: 0.03, 0.15), household assets score (β: 0.64, 95% CI: 0.24, 1.04), and HOME child cleanliness factor (β: 0.60, 95% CI: 0.05, 1.15). In multivariable models, the mean rate of enteropathogen detections, burden of illness, and complementary food intakes between birth and 2 y were not significantly related to 5-y cognition. CONCLUSIONS: A nurturing home context in terms of a healthy/clean environment and household wealth, provision of adequate micronutrients, maternal education, and cognitive reasoning have a strong and persistent influence on child cognitive development. Efforts addressing aspects of poverty around micronutrient status, nurturing caregiving, and enabling home environments are likely to have lasting positive impacts on child cognitive development.
format Online
Article
Text
id pubmed-6686051
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-66860512019-08-14 Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED McCormick, Benjamin J J Richard, Stephanie A Caulfield, Laura E Pendergast, Laura L Seidman, Jessica C Koshy, Beena Roshan, Reeba Shrestha, Rita Svensen, Erling Blacy, Ladislaus Rasmussen, Zeba Maphula, Angelina Scharf, Rebecca Nahar, Baitun Haque, Sayma Rasheed, Muneera Oria, Reinaldo Rogawski, Elizabeth T Murray-Kolb, Laura E J Nutr Original Research Article BACKGROUND: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown. OBJECTIVE: The aim of this study was to examine the relation between early-life factors (birth to 2 y) and cognitive development at 5 y. METHODS: Observational follow-up visits were made of children at 5 y, previously enrolled in the community-based MAL-ED longitudinal cohort. The burden of enteropathogens, prevalence of illness, complementary diet intake, micronutrient status, and household and maternal factors from birth to 2 y were extensively measured and their relation with the Wechsler Preschool Primary Scales of Intelligence at 5 y was examined through use of linear regression. RESULTS: Cognitive T-scores from 813 of 1198 (68%) children were examined and 5 variables had significant associations in multivariable models: mean child plasma transferrin receptor concentration (β: −1.81, 95% CI: −2.75, −0.86), number of years of maternal education (β: 0.27, 95% CI: 0.08, 0.45), maternal cognitive reasoning score (β: 0.09, 95% CI: 0.03, 0.15), household assets score (β: 0.64, 95% CI: 0.24, 1.04), and HOME child cleanliness factor (β: 0.60, 95% CI: 0.05, 1.15). In multivariable models, the mean rate of enteropathogen detections, burden of illness, and complementary food intakes between birth and 2 y were not significantly related to 5-y cognition. CONCLUSIONS: A nurturing home context in terms of a healthy/clean environment and household wealth, provision of adequate micronutrients, maternal education, and cognitive reasoning have a strong and persistent influence on child cognitive development. Efforts addressing aspects of poverty around micronutrient status, nurturing caregiving, and enabling home environments are likely to have lasting positive impacts on child cognitive development. Oxford University Press 2019-08 2019-06-04 /pmc/articles/PMC6686051/ /pubmed/31162601 http://dx.doi.org/10.1093/jn/nxz055 Text en Copyright © American Society for Nutrition 2019. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
McCormick, Benjamin J J
Richard, Stephanie A
Caulfield, Laura E
Pendergast, Laura L
Seidman, Jessica C
Koshy, Beena
Roshan, Reeba
Shrestha, Rita
Svensen, Erling
Blacy, Ladislaus
Rasmussen, Zeba
Maphula, Angelina
Scharf, Rebecca
Nahar, Baitun
Haque, Sayma
Rasheed, Muneera
Oria, Reinaldo
Rogawski, Elizabeth T
Murray-Kolb, Laura E
Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED
title Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED
title_full Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED
title_fullStr Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED
title_full_unstemmed Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED
title_short Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED
title_sort early life child micronutrient status, maternal reasoning, and a nurturing household environment have persistent influences on child cognitive development at age 5 years: results from mal-ed
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686051/
https://www.ncbi.nlm.nih.gov/pubmed/31162601
http://dx.doi.org/10.1093/jn/nxz055
work_keys_str_mv AT mccormickbenjaminjj earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT richardstephaniea earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT caulfieldlaurae earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT pendergastlaural earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT seidmanjessicac earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT koshybeena earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT roshanreeba earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT shrestharita earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT svensenerling earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT blacyladislaus earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT rasmussenzeba earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT maphulaangelina earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT scharfrebecca earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT naharbaitun earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT haquesayma earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT rasheedmuneera earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT oriareinaldo earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT rogawskielizabetht earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT murraykolblaurae earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled
AT earlylifechildmicronutrientstatusmaternalreasoningandanurturinghouseholdenvironmenthavepersistentinfluencesonchildcognitivedevelopmentatage5yearsresultsfrommaled