Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei

In the search for effective and sustainable drugs for human African trypanosomiasis (HAT), we developed hybrid compounds by merging the structural features of quinone 4 (2‐phenoxynaphthalene‐1,4‐dione) with those of phenolic constituents from cashew nut shell liquid (CNSL). CNSL is a waste product f...

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Detalles Bibliográficos
Autores principales: Cerone, Michela, Uliassi, Elisa, Prati, Federica, Ebiloma, Godwin U., Lemgruber, Leandro, Bergamini, Christian, Watson, David G., de A. M. Ferreira, Thais, Roth Cardoso, Gabriella Simões Heyn, Soares Romeiro, Luiz A., de Koning, Harry P., Bolognesi, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686156/
https://www.ncbi.nlm.nih.gov/pubmed/30664325
http://dx.doi.org/10.1002/cmdc.201800790

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