miR-448 targets IDO1 and regulates CD8(+) T cell response in human colon cancer

BACKGROUND: Indoleamine 2,3-dioxygenase 1 (IDO1) is a critical regulator of T cell function, contributing to immune tolerance. Upregulation of IDO1 has been found in many cancer types; however, the regulatory mechanisms and clinical significance of IDO1 in colon cancer are still unclear. Here, we in...

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Detalles Bibliográficos
Autores principales: Lou, Qiong, Liu, Ruixian, Yang, Xiangling, Li, Weiqian, Huang, Lanlan, Wei, Lili, Tan, Huiliu, Xiang, Nanlin, Chan, Kawo, Chen, Junxiong, Liu, Huanliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686234/
https://www.ncbi.nlm.nih.gov/pubmed/31391111
http://dx.doi.org/10.1186/s40425-019-0691-0

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