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Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers

INTRODUCTION: Data on the use of Xpert Mtb/Rif for the diagnosis of intestinal tuberculosis is sparse. We report on the utility of Xpert Mtb/Rif testing for diagnosis of intestinal tuberculosis (ITB) in patients with ileocecal ulcers METHODOLOGY: We performed a retrospective analysis of patients wit...

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Autores principales: Bellam, Balaji L, Mandavdhare, Harshal S, Sharma, Kusum, Shukla, Siddharth, Soni, Hariom, Kumar-M, Praveen, Singh, Harjeet, Prasad, Kaushal K, Dutta, Usha, Sharma, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686322/
https://www.ncbi.nlm.nih.gov/pubmed/31431826
http://dx.doi.org/10.1177/2049936119863939
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author Bellam, Balaji L
Mandavdhare, Harshal S
Sharma, Kusum
Shukla, Siddharth
Soni, Hariom
Kumar-M, Praveen
Singh, Harjeet
Prasad, Kaushal K
Dutta, Usha
Sharma, Vishal
author_facet Bellam, Balaji L
Mandavdhare, Harshal S
Sharma, Kusum
Shukla, Siddharth
Soni, Hariom
Kumar-M, Praveen
Singh, Harjeet
Prasad, Kaushal K
Dutta, Usha
Sharma, Vishal
author_sort Bellam, Balaji L
collection PubMed
description INTRODUCTION: Data on the use of Xpert Mtb/Rif for the diagnosis of intestinal tuberculosis is sparse. We report on the utility of Xpert Mtb/Rif testing for diagnosis of intestinal tuberculosis (ITB) in patients with ileocecal ulcers METHODOLOGY: We performed a retrospective analysis of patients with ileocecal ulcers and suspected to have ITB and in whom testing of intestinal tissue for Xpert Mtb/Rif was performed. The patients were divided into two groups: those with a final diagnosis of intestinal tuberculosis and those with other diagnosis. These patients were compared for clinical features and presentation. The sensitivity, specificity, positive predictive value, and negative predictive value of Xpert Mtb/Rif for the diagnosis of ITB were calculated. RESULTS: Of the 40 patients studied, 23 were women and the mean age was 32.92 ± 12.78 years. Abdominal pain was present in 33 (88.5%) patients and diarrhea in 12 (30%). A total of 25 patients had underlying ITB whereas 15 patients had other diagnoses (Crohn’s disease, amebiasis, nonspecific ileitis, etc.). The sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of GeneXpert-Mtb/Rif was 32% (CI: 14.95–53.50%), 100% (78.2–100), 46.88% (40.27–53.59%), 100 & 57.50 (40.89–72.89%) respectively. CONCLUSION: A positive GeneXpert-Mtb/Rif helps in the diagnosis of ITB, but the sensitivity is low.
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spelling pubmed-66863222019-08-20 Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers Bellam, Balaji L Mandavdhare, Harshal S Sharma, Kusum Shukla, Siddharth Soni, Hariom Kumar-M, Praveen Singh, Harjeet Prasad, Kaushal K Dutta, Usha Sharma, Vishal Ther Adv Infect Dis Original Research INTRODUCTION: Data on the use of Xpert Mtb/Rif for the diagnosis of intestinal tuberculosis is sparse. We report on the utility of Xpert Mtb/Rif testing for diagnosis of intestinal tuberculosis (ITB) in patients with ileocecal ulcers METHODOLOGY: We performed a retrospective analysis of patients with ileocecal ulcers and suspected to have ITB and in whom testing of intestinal tissue for Xpert Mtb/Rif was performed. The patients were divided into two groups: those with a final diagnosis of intestinal tuberculosis and those with other diagnosis. These patients were compared for clinical features and presentation. The sensitivity, specificity, positive predictive value, and negative predictive value of Xpert Mtb/Rif for the diagnosis of ITB were calculated. RESULTS: Of the 40 patients studied, 23 were women and the mean age was 32.92 ± 12.78 years. Abdominal pain was present in 33 (88.5%) patients and diarrhea in 12 (30%). A total of 25 patients had underlying ITB whereas 15 patients had other diagnoses (Crohn’s disease, amebiasis, nonspecific ileitis, etc.). The sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of GeneXpert-Mtb/Rif was 32% (CI: 14.95–53.50%), 100% (78.2–100), 46.88% (40.27–53.59%), 100 & 57.50 (40.89–72.89%) respectively. CONCLUSION: A positive GeneXpert-Mtb/Rif helps in the diagnosis of ITB, but the sensitivity is low. SAGE Publications 2019-08-07 /pmc/articles/PMC6686322/ /pubmed/31431826 http://dx.doi.org/10.1177/2049936119863939 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Bellam, Balaji L
Mandavdhare, Harshal S
Sharma, Kusum
Shukla, Siddharth
Soni, Hariom
Kumar-M, Praveen
Singh, Harjeet
Prasad, Kaushal K
Dutta, Usha
Sharma, Vishal
Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
title Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
title_full Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
title_fullStr Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
title_full_unstemmed Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
title_short Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
title_sort utility of tissue xpert-mtb/rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686322/
https://www.ncbi.nlm.nih.gov/pubmed/31431826
http://dx.doi.org/10.1177/2049936119863939
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