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Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish

Parasite‐mediated selection is one of the main drivers of genetic variation in natural populations. The persistence of long‐term self‐fertilization, however, challenges the notion that low genetic variation and inbreeding compromise the host's ability to respond to pathogens. DNA methylation re...

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Autores principales: Berbel‐Filho, Waldir M., Garcia de Leaniz, Carlos, Morán, Paloma, Cable, Joanne, Lima, Sergio M. Q., Consuegra, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686343/
https://www.ncbi.nlm.nih.gov/pubmed/31410276
http://dx.doi.org/10.1002/ece3.5426
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author Berbel‐Filho, Waldir M.
Garcia de Leaniz, Carlos
Morán, Paloma
Cable, Joanne
Lima, Sergio M. Q.
Consuegra, Sofia
author_facet Berbel‐Filho, Waldir M.
Garcia de Leaniz, Carlos
Morán, Paloma
Cable, Joanne
Lima, Sergio M. Q.
Consuegra, Sofia
author_sort Berbel‐Filho, Waldir M.
collection PubMed
description Parasite‐mediated selection is one of the main drivers of genetic variation in natural populations. The persistence of long‐term self‐fertilization, however, challenges the notion that low genetic variation and inbreeding compromise the host's ability to respond to pathogens. DNA methylation represents a potential mechanism for generating additional adaptive variation under low genetic diversity. We compared genetic diversity (microsatellites and AFLPs), variation in DNA methylation (MS‐AFLPs), and parasite loads in three populations of Kryptolebias hermaphroditus, a predomintanly self‐fertilizing fish, to analyze the potential adaptive value of DNA methylation in relation to genetic diversity and parasite loads. We found strong genetic population structuring, as well as differences in parasite loads and methylation levels among sampling sites and selfing lineages. Globally, the interaction between parasites and inbreeding with selfing lineages influenced DNA methylation, but parasites seemed more important in determining methylation levels at the local scale.
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spelling pubmed-66863432019-08-13 Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish Berbel‐Filho, Waldir M. Garcia de Leaniz, Carlos Morán, Paloma Cable, Joanne Lima, Sergio M. Q. Consuegra, Sofia Ecol Evol Original Research Parasite‐mediated selection is one of the main drivers of genetic variation in natural populations. The persistence of long‐term self‐fertilization, however, challenges the notion that low genetic variation and inbreeding compromise the host's ability to respond to pathogens. DNA methylation represents a potential mechanism for generating additional adaptive variation under low genetic diversity. We compared genetic diversity (microsatellites and AFLPs), variation in DNA methylation (MS‐AFLPs), and parasite loads in three populations of Kryptolebias hermaphroditus, a predomintanly self‐fertilizing fish, to analyze the potential adaptive value of DNA methylation in relation to genetic diversity and parasite loads. We found strong genetic population structuring, as well as differences in parasite loads and methylation levels among sampling sites and selfing lineages. Globally, the interaction between parasites and inbreeding with selfing lineages influenced DNA methylation, but parasites seemed more important in determining methylation levels at the local scale. John Wiley and Sons Inc. 2019-07-15 /pmc/articles/PMC6686343/ /pubmed/31410276 http://dx.doi.org/10.1002/ece3.5426 Text en © 2019 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Berbel‐Filho, Waldir M.
Garcia de Leaniz, Carlos
Morán, Paloma
Cable, Joanne
Lima, Sergio M. Q.
Consuegra, Sofia
Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
title Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
title_full Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
title_fullStr Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
title_full_unstemmed Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
title_short Local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
title_sort local parasite pressures and host genotype modulate epigenetic diversity in a mixed‐mating fish
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686343/
https://www.ncbi.nlm.nih.gov/pubmed/31410276
http://dx.doi.org/10.1002/ece3.5426
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