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Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament

STUDY DESIGN: Case-control study. OBJECTIVES: To determine the possible pathogenesis of ossification of the posterior longitudinal ligament (OPLL) in regard to the serum concentration of fibroblast growth factor 23 (FGF-23). METHODS: The study included 95 patients with OPLL and a control group of 73...

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Autores principales: Kawaguchi, Yoshiharu, Kitajima, Isao, Nakano, Masato, Yasuda, Taketoshi, Seki, Shoji, Suzuki, Kayo, Yahara, Yasuhito, Makino, Hiroto, Ujihara, Yasuhiro, Ueno, Tomohiro, Kimura, Tomoatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686384/
https://www.ncbi.nlm.nih.gov/pubmed/31431871
http://dx.doi.org/10.1177/2192568218801015
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author Kawaguchi, Yoshiharu
Kitajima, Isao
Nakano, Masato
Yasuda, Taketoshi
Seki, Shoji
Suzuki, Kayo
Yahara, Yasuhito
Makino, Hiroto
Ujihara, Yasuhiro
Ueno, Tomohiro
Kimura, Tomoatsu
author_facet Kawaguchi, Yoshiharu
Kitajima, Isao
Nakano, Masato
Yasuda, Taketoshi
Seki, Shoji
Suzuki, Kayo
Yahara, Yasuhito
Makino, Hiroto
Ujihara, Yasuhiro
Ueno, Tomohiro
Kimura, Tomoatsu
author_sort Kawaguchi, Yoshiharu
collection PubMed
description STUDY DESIGN: Case-control study. OBJECTIVES: To determine the possible pathogenesis of ossification of the posterior longitudinal ligament (OPLL) in regard to the serum concentration of fibroblast growth factor 23 (FGF-23). METHODS: The study included 95 patients with OPLL and a control group of 73 age- and sex-matched volunteers. The serum concentrations of FGF-23, creatinine (Cre), alkaline phosphatase, calcium (Ca), inorganic phosphate (Pi), and hypersensitive C-reactive protein (hs-CRP) were analyzed from blood samples, and Cre, Ca, Pi, and tubular reabsorption of phosphate were measured using urine samples. We evaluated the severity of ossified spinal lesions in patients with OPLL according to the ossification index (the OP index and the OS index). Data was compared between the OPLL and control group and between the OPLL progression and no progression group. RESULTS: Serum FGF-23 and hs-CRP were higher, and serum Pi was lower in patients with OPLL than in the controls. There was a positive correlation between FGF-23 and hs-CRP and a negative correlation between serum Pi and the OS index; however, the correlations were very weak. Overall, 31.7% of patients had progression of OPLL during follow-up. FGF-23 and hs-CRP were higher in the progression group than in the no progression group. CONCLUSIONS: These results might indicate that FGF-23 and hs-CRP are positive markers for OPLL. Phosphate metabolism via FGF-23 might be a target for future study on the pathogenesis of OPLL.
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spelling pubmed-66863842019-08-20 Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament Kawaguchi, Yoshiharu Kitajima, Isao Nakano, Masato Yasuda, Taketoshi Seki, Shoji Suzuki, Kayo Yahara, Yasuhito Makino, Hiroto Ujihara, Yasuhiro Ueno, Tomohiro Kimura, Tomoatsu Global Spine J Original Articles STUDY DESIGN: Case-control study. OBJECTIVES: To determine the possible pathogenesis of ossification of the posterior longitudinal ligament (OPLL) in regard to the serum concentration of fibroblast growth factor 23 (FGF-23). METHODS: The study included 95 patients with OPLL and a control group of 73 age- and sex-matched volunteers. The serum concentrations of FGF-23, creatinine (Cre), alkaline phosphatase, calcium (Ca), inorganic phosphate (Pi), and hypersensitive C-reactive protein (hs-CRP) were analyzed from blood samples, and Cre, Ca, Pi, and tubular reabsorption of phosphate were measured using urine samples. We evaluated the severity of ossified spinal lesions in patients with OPLL according to the ossification index (the OP index and the OS index). Data was compared between the OPLL and control group and between the OPLL progression and no progression group. RESULTS: Serum FGF-23 and hs-CRP were higher, and serum Pi was lower in patients with OPLL than in the controls. There was a positive correlation between FGF-23 and hs-CRP and a negative correlation between serum Pi and the OS index; however, the correlations were very weak. Overall, 31.7% of patients had progression of OPLL during follow-up. FGF-23 and hs-CRP were higher in the progression group than in the no progression group. CONCLUSIONS: These results might indicate that FGF-23 and hs-CRP are positive markers for OPLL. Phosphate metabolism via FGF-23 might be a target for future study on the pathogenesis of OPLL. SAGE Publications 2018-09-27 2019-08 /pmc/articles/PMC6686384/ /pubmed/31431871 http://dx.doi.org/10.1177/2192568218801015 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (http://www.creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Kawaguchi, Yoshiharu
Kitajima, Isao
Nakano, Masato
Yasuda, Taketoshi
Seki, Shoji
Suzuki, Kayo
Yahara, Yasuhito
Makino, Hiroto
Ujihara, Yasuhiro
Ueno, Tomohiro
Kimura, Tomoatsu
Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
title Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
title_full Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
title_fullStr Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
title_full_unstemmed Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
title_short Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
title_sort increase of the serum fgf-23 in ossification of the posterior longitudinal ligament
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686384/
https://www.ncbi.nlm.nih.gov/pubmed/31431871
http://dx.doi.org/10.1177/2192568218801015
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