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Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants
BACKGROUND: In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addition, the statistics of germline variants frequencies in healthy individuals an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686424/ https://www.ncbi.nlm.nih.gov/pubmed/31391007 http://dx.doi.org/10.1186/s12885-019-5994-5 |