Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants

BACKGROUND: In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addition, the statistics of germline variants frequencies in healthy individuals an...

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Detalles Bibliográficos
Autores principales: Rasnic, Roni, Brandes, Nadav, Zuk, Or, Linial, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686424/
https://www.ncbi.nlm.nih.gov/pubmed/31391007
http://dx.doi.org/10.1186/s12885-019-5994-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686424/
https://www.ncbi.nlm.nih.gov/pubmed/31391007
http://dx.doi.org/10.1186/s12885-019-5994-5

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