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Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants

BACKGROUND: In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addition, the statistics of germline variants frequencies in healthy individuals an...

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Detalles Bibliográficos
Autores principales:	Rasnic, Roni, Brandes, Nadav, Zuk, Or, Linial, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686424/ https://www.ncbi.nlm.nih.gov/pubmed/31391007 http://dx.doi.org/10.1186/s12885-019-5994-5

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