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Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention

BACKGROUND: The SELPHI study (An HIV Self-Testing Public Health Intervention) is an online randomised controlled trial (RCT) of HIV self-testing (HIVST). The aim of this study was to assess the feasibility of recruiting UK men who have sex with men (cis and trans) and trans women who have sex with m...

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Autores principales: Witzel, T. Charles, Gabriel, Michelle M., McCabe, Leanne, Weatherburn, Peter, Gafos, Mitzy, Speakman, Andrew, Pebody, Roger, Burns, Fiona M., Bonell, Chris, Lampe, Fiona C., Dunn, David T., Ward, Denise, Harbottle, Justin, Phillips, Andrew N., McCormack, Sheena, Rodger, Alison J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686516/
https://www.ncbi.nlm.nih.gov/pubmed/31391003
http://dx.doi.org/10.1186/s12879-019-4247-1
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author Witzel, T. Charles
Gabriel, Michelle M.
McCabe, Leanne
Weatherburn, Peter
Gafos, Mitzy
Speakman, Andrew
Pebody, Roger
Burns, Fiona M.
Bonell, Chris
Lampe, Fiona C.
Dunn, David T.
Ward, Denise
Harbottle, Justin
Phillips, Andrew N.
McCormack, Sheena
Rodger, Alison J.
author_facet Witzel, T. Charles
Gabriel, Michelle M.
McCabe, Leanne
Weatherburn, Peter
Gafos, Mitzy
Speakman, Andrew
Pebody, Roger
Burns, Fiona M.
Bonell, Chris
Lampe, Fiona C.
Dunn, David T.
Ward, Denise
Harbottle, Justin
Phillips, Andrew N.
McCormack, Sheena
Rodger, Alison J.
author_sort Witzel, T. Charles
collection PubMed
description BACKGROUND: The SELPHI study (An HIV Self-Testing Public Health Intervention) is an online randomised controlled trial (RCT) of HIV self-testing (HIVST). The aim of this study was to assess the feasibility of recruiting UK men who have sex with men (cis and trans) and trans women who have sex with men to the SELPHI pilot, and the acceptability of the HIVST intervention used among those randomised to receive a kit. METHODS: A mixed-methods approach to assessing trial feasibility and intervention acceptability was taken, using quantitative data from advertising sources and RCT surveys alongside qualitative data from a nested sub-study. RESULTS: Online recruitment and intervention delivery was feasible. The recruitment strategy led to the registration of 1370 participants of whom 76% (1035) successfully enrolled and were randomised 60/40 to baseline testing vs no baseline testing. Advertising platforms performed variably. Reported HIVST kit use increased from 83% at two weeks to 96% at three months. Acceptability was very high across all quantitative measures. Participants described the instructions as easy to use, and the testing process as simple. The support structures in SELPHI were felt to be adequate. Described emotional responses to HIVST varied. CONCLUSIONS: Recruiting to a modest sized HIVST pilot RCT is feasible, and the recruitment, intervention and HIVST kit were acceptable. Research on support needs of individuals with reactive results is warranted. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-019-4247-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-66865162019-08-12 Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention Witzel, T. Charles Gabriel, Michelle M. McCabe, Leanne Weatherburn, Peter Gafos, Mitzy Speakman, Andrew Pebody, Roger Burns, Fiona M. Bonell, Chris Lampe, Fiona C. Dunn, David T. Ward, Denise Harbottle, Justin Phillips, Andrew N. McCormack, Sheena Rodger, Alison J. BMC Infect Dis Research Article BACKGROUND: The SELPHI study (An HIV Self-Testing Public Health Intervention) is an online randomised controlled trial (RCT) of HIV self-testing (HIVST). The aim of this study was to assess the feasibility of recruiting UK men who have sex with men (cis and trans) and trans women who have sex with men to the SELPHI pilot, and the acceptability of the HIVST intervention used among those randomised to receive a kit. METHODS: A mixed-methods approach to assessing trial feasibility and intervention acceptability was taken, using quantitative data from advertising sources and RCT surveys alongside qualitative data from a nested sub-study. RESULTS: Online recruitment and intervention delivery was feasible. The recruitment strategy led to the registration of 1370 participants of whom 76% (1035) successfully enrolled and were randomised 60/40 to baseline testing vs no baseline testing. Advertising platforms performed variably. Reported HIVST kit use increased from 83% at two weeks to 96% at three months. Acceptability was very high across all quantitative measures. Participants described the instructions as easy to use, and the testing process as simple. The support structures in SELPHI were felt to be adequate. Described emotional responses to HIVST varied. CONCLUSIONS: Recruiting to a modest sized HIVST pilot RCT is feasible, and the recruitment, intervention and HIVST kit were acceptable. Research on support needs of individuals with reactive results is warranted. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-019-4247-1) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-08 /pmc/articles/PMC6686516/ /pubmed/31391003 http://dx.doi.org/10.1186/s12879-019-4247-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Witzel, T. Charles
Gabriel, Michelle M.
McCabe, Leanne
Weatherburn, Peter
Gafos, Mitzy
Speakman, Andrew
Pebody, Roger
Burns, Fiona M.
Bonell, Chris
Lampe, Fiona C.
Dunn, David T.
Ward, Denise
Harbottle, Justin
Phillips, Andrew N.
McCormack, Sheena
Rodger, Alison J.
Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention
title Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention
title_full Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention
title_fullStr Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention
title_full_unstemmed Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention
title_short Pilot phase of an internet-based RCT of HIVST targeting MSM and transgender people in England and Wales: advertising strategies and acceptability of the intervention
title_sort pilot phase of an internet-based rct of hivst targeting msm and transgender people in england and wales: advertising strategies and acceptability of the intervention
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686516/
https://www.ncbi.nlm.nih.gov/pubmed/31391003
http://dx.doi.org/10.1186/s12879-019-4247-1
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