5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery

A case of high anion gap metabolic acidosis (HAGMA) and high level of 5-oxoprolinuria were noticed in an elderly female of 66 years who had multiple risk/precipitating factors and recovered well with N-acetyl cysteine infusion. This is reported in view of its rarity and to create awareness of this e...

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Autores principales: Senthilkumaran, Subramanian, Benita, Florence, Nath Jena, Narendra, Sasikumar, Sambathkumar, Thirumalaikolundusubramanian, Ponniah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686586/
https://www.ncbi.nlm.nih.gov/pubmed/31406447
http://dx.doi.org/10.5005/jp-journals-10071-23211
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author Senthilkumaran, Subramanian
Benita, Florence
Nath Jena, Narendra
Sasikumar, Sambathkumar
Thirumalaikolundusubramanian, Ponniah
author_facet Senthilkumaran, Subramanian
Benita, Florence
Nath Jena, Narendra
Sasikumar, Sambathkumar
Thirumalaikolundusubramanian, Ponniah
author_sort Senthilkumaran, Subramanian
collection PubMed
description A case of high anion gap metabolic acidosis (HAGMA) and high level of 5-oxoprolinuria were noticed in an elderly female of 66 years who had multiple risk/precipitating factors and recovered well with N-acetyl cysteine infusion. This is reported in view of its rarity and to create awareness of this entity among medical students and practicing physicians who handles such cases in emergency room or critical care unit. Moreover they have to remember and investigate the cases of metabolic acidosis for 5-oxoprolinuia especially in susceptible individuals who are on paracetamol with or without other precipitating factors. HOW TO CITE THIS ARTICLE: Senthilkumaran S, Benita F, Jena NN, Sasikumar S, Thirumalaikolundusubramanian P. 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery. Indian J Crit Care Med 2019;23(7):342–343.
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spelling pubmed-66865862019-08-12 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery Senthilkumaran, Subramanian Benita, Florence Nath Jena, Narendra Sasikumar, Sambathkumar Thirumalaikolundusubramanian, Ponniah Indian J Crit Care Med Case Report A case of high anion gap metabolic acidosis (HAGMA) and high level of 5-oxoprolinuria were noticed in an elderly female of 66 years who had multiple risk/precipitating factors and recovered well with N-acetyl cysteine infusion. This is reported in view of its rarity and to create awareness of this entity among medical students and practicing physicians who handles such cases in emergency room or critical care unit. Moreover they have to remember and investigate the cases of metabolic acidosis for 5-oxoprolinuia especially in susceptible individuals who are on paracetamol with or without other precipitating factors. HOW TO CITE THIS ARTICLE: Senthilkumaran S, Benita F, Jena NN, Sasikumar S, Thirumalaikolundusubramanian P. 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery. Indian J Crit Care Med 2019;23(7):342–343. Jaypee Brothers Medical Publishers 2019-07 /pmc/articles/PMC6686586/ /pubmed/31406447 http://dx.doi.org/10.5005/jp-journals-10071-23211 Text en Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Case Report
Senthilkumaran, Subramanian
Benita, Florence
Nath Jena, Narendra
Sasikumar, Sambathkumar
Thirumalaikolundusubramanian, Ponniah
5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery
title 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery
title_full 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery
title_fullStr 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery
title_full_unstemmed 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery
title_short 5-oxoprolinuria (Pyroglutamic Aciduria) and Metabolic Acidosis: Unraveling the Mystery
title_sort 5-oxoprolinuria (pyroglutamic aciduria) and metabolic acidosis: unraveling the mystery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686586/
https://www.ncbi.nlm.nih.gov/pubmed/31406447
http://dx.doi.org/10.5005/jp-journals-10071-23211
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