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Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting
We have synthesised a range of thiazole orange (TO) functionalised oligonucleotides for nucleic acid detection in which TO is attached to the nucleobase or sugar of thymidine. The properties of duplexes between TO-probes and their DNA and RNA targets strongly depend on the length of the linker betwe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686645/ https://www.ncbi.nlm.nih.gov/pubmed/31157811 http://dx.doi.org/10.1039/c9ob00885c |