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Evaluation and Reduction of CRISPR Off-Target Cleavage Events

Introduction of CRISPR/Cas9 methods (clustered regularly interspaced short palindromic repeats, CRISPR-associated protein 9) have led to a huge surge in the use of precision genome editing for research applications. Translational medical efforts are likewise rapidly progressing, and Phase I clinical...

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Detalles Bibliográficos
Autores principales: Vakulskas, Christopher A., Behlke, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686686/
https://www.ncbi.nlm.nih.gov/pubmed/31107154
http://dx.doi.org/10.1089/nat.2019.0790