Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

PURPOSE: The degenerative corneal disease keratoconus is a leading indicator for corneal transplant with an unknown etiology. We recently identified the activation of the integrated stress response (ISR) in ex vivo human corneas and in vitro cell culture. Utilizing small molecules to modulate the IS...

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Detalles Bibliográficos
Autores principales: Soiberman, Uri Simcha, Shehata, Ahmed Elsayed Mahmoud, Lu, Michelle Xiaoyi, Young, Tempest, Daoud, Yassine J., Chakravarti, Shukti, Jun, Albert S., Foster, James William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686743/
https://www.ncbi.nlm.nih.gov/pubmed/31390655
http://dx.doi.org/10.1167/iovs.19-27151

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