IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here we show that IMP dehydrogenase-2 (IMPDH2), the rat...

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Detalles Bibliográficos
Autores principales: Kofuji, Satoshi, Hirayama, Akiyoshi, Eberhardt, Alexander Otto, Kawaguchi, Risa, Sugiura, Yuki, Sampetrean, Oltea, Ikeda, Yoshiki, Warren, Mikako, Sakamoto, Naoya, Kitahara, Shuji, Yoshino, Hirofumi, Yamashita, Daisuke, Sumita, Kazutaka, Wolfe, Kara, Lange, Lisa, Ikeda, Satsuki, Shimada, Hiroko, Minami, Noriaki, Malhotra, Akshiv, Morioka, Shin, Ban, Yuki, Asano, Maya, Flanary, Victoria L, Ramkissoon, Annmarie, Chow, Lionel M.L., Kiyokawa, Juri, Mashimo, Tomoyuki, Lucey, Greg, Mareninov, Sergey, Ozawa, Tatsuya, Onishi, Nobuyuki, Okumura, Koichi, Terakawa, Jumpei, Daikoku, Takiko, Wise-Draper, Trisha, Majd, Nazanin, Kofuji, Kaori, Sasaki, Mika, Mori, Masaru, Kanemura, Yonehiro, Smith, Eric P., Anastasiou, Dimitrios, Wakimoto, Hiroaki, Holland, Eric C., Yong, William H., Horbinski, Craig, Nakano, Ichiro, DeBerardinis, Ralph J., Bachoo, Robert M., Mischel, Paul S., Yasui, Wataru, Suematsu, Makoto, Saya, Hideyuki, Soga, Tomoyoshi, Grummt, Ingrid, Bierhoff, Holger, Sasaki, Atsuo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686884/
https://www.ncbi.nlm.nih.gov/pubmed/31371825
http://dx.doi.org/10.1038/s41556-019-0363-9

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