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Cux1 regulation of the cyclin kinase inhibitor p27(kip1) in polycystic kidney disease is attenuated by HDAC inhibitors

Cux1 is a homeodomain protein involved in cell cycle regulation and kidney development. Cux1 represses the cyclin kinase inhibitor p27 during early kidney development, promoting cell proliferation in the nephrogenic zone. Promoter reporter analysis of p27 revealed that Cux1 represses p27 in a concen...

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Detalles Bibliográficos
Autores principales:	Livingston, Safia, Carlton, Carol, Sharma, Madhulika, Kearns, Donovan, Baybutt, Richard, Vanden Heuvel, Gregory B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687066/ https://www.ncbi.nlm.nih.gov/pubmed/31396588 http://dx.doi.org/10.1016/j.gene.2019.100007

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