Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation

Arthropod-borne flaviviruses cause life-threatening diseases associated with endothelial hyperpermeability and vascular leak. We recently found that vascular leak can be triggered by dengue virus (DENV) non-structural protein 1 (NS1) via the disruption of the endothelial glycocalyx-like layer (EGL)....

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Detalles Bibliográficos
Autores principales: Wang, Chunling, Puerta-Guardo, Henry, Biering, Scott B., Glasner, Dustin R., Tran, Edwina B., Patana, Mark, Gomberg, Trent A., Malvar, Carmel, Lo, Nicholas T. N., Espinosa, Diego A., Harris, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687192/
https://www.ncbi.nlm.nih.gov/pubmed/31356638
http://dx.doi.org/10.1371/journal.ppat.1007938

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