Cargando…

Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study

BACKGROUND: Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. METHODS: The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based...

Descripción completa

Detalles Bibliográficos
Autores principales: Alves Soares, Emmanuel, Lazera, Márcia dos Santos, Wanke, Bodo, de Faria Ferreira, Marcela, Carvalhaes de Oliveira, Raquel Vasconcellos, Oliveira, Adeno Gonçalves, Coutinho, Ziadir Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687200/
https://www.ncbi.nlm.nih.gov/pubmed/31356603
http://dx.doi.org/10.1371/journal.pntd.0007569
_version_ 1783442699040325632
author Alves Soares, Emmanuel
Lazera, Márcia dos Santos
Wanke, Bodo
de Faria Ferreira, Marcela
Carvalhaes de Oliveira, Raquel Vasconcellos
Oliveira, Adeno Gonçalves
Coutinho, Ziadir Francisco
author_facet Alves Soares, Emmanuel
Lazera, Márcia dos Santos
Wanke, Bodo
de Faria Ferreira, Marcela
Carvalhaes de Oliveira, Raquel Vasconcellos
Oliveira, Adeno Gonçalves
Coutinho, Ziadir Francisco
author_sort Alves Soares, Emmanuel
collection PubMed
description BACKGROUND: Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. METHODS: The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). RESULTS: Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina (70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. CONCLUSIONS: This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil.
format Online
Article
Text
id pubmed-6687200
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-66872002019-08-15 Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study Alves Soares, Emmanuel Lazera, Márcia dos Santos Wanke, Bodo de Faria Ferreira, Marcela Carvalhaes de Oliveira, Raquel Vasconcellos Oliveira, Adeno Gonçalves Coutinho, Ziadir Francisco PLoS Negl Trop Dis Research Article BACKGROUND: Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. METHODS: The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). RESULTS: Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina (70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. CONCLUSIONS: This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil. Public Library of Science 2019-07-29 /pmc/articles/PMC6687200/ /pubmed/31356603 http://dx.doi.org/10.1371/journal.pntd.0007569 Text en © 2019 Alves Soares et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alves Soares, Emmanuel
Lazera, Márcia dos Santos
Wanke, Bodo
de Faria Ferreira, Marcela
Carvalhaes de Oliveira, Raquel Vasconcellos
Oliveira, Adeno Gonçalves
Coutinho, Ziadir Francisco
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study
title Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study
title_full Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study
title_fullStr Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study
title_full_unstemmed Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study
title_short Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study
title_sort mortality by cryptococcosis in brazil from 2000 to 2012: a descriptive epidemiological study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687200/
https://www.ncbi.nlm.nih.gov/pubmed/31356603
http://dx.doi.org/10.1371/journal.pntd.0007569
work_keys_str_mv AT alvessoaresemmanuel mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy
AT lazeramarciadossantos mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy
AT wankebodo mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy
AT defariaferreiramarcela mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy
AT carvalhaesdeoliveiraraquelvasconcellos mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy
AT oliveiraadenogoncalves mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy
AT coutinhoziadirfrancisco mortalitybycryptococcosisinbrazilfrom2000to2012adescriptiveepidemiologicalstudy