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The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population

BACKGROUND: Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. METHODS: A total of 381 patients with coronary heart disease...

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Autores principales: Liu, Xiumin, Li, Yujie, Zhang, Huan, Ji, Yuqiang, Zhao, Zhao, Wang, Changyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687643/
https://www.ncbi.nlm.nih.gov/pubmed/31270966
http://dx.doi.org/10.1002/mgg3.835
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author Liu, Xiumin
Li, Yujie
Zhang, Huan
Ji, Yuqiang
Zhao, Zhao
Wang, Changyu
author_facet Liu, Xiumin
Li, Yujie
Zhang, Huan
Ji, Yuqiang
Zhao, Zhao
Wang, Changyu
author_sort Liu, Xiumin
collection PubMed
description BACKGROUND: Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. METHODS: A total of 381 patients with coronary heart disease were recruited. Based on complete cardiac examination, the patients were divided into two subgroups: 185 patients with AF and 196 patients without AF. An association analysis was performed using 13 genotyped SNPs. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by conditional logistic regression. RESULTS: In our research, we found that KCNE2 rs8134775 was associated with a decreased AF risk in the allele model (OR = 0.70; 95% CI: 0.50–0.97; p = 0.034). Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19–0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20–4.42; p = 0.012). CONCLUSIONS: Our results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF.
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spelling pubmed-66876432019-08-14 The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population Liu, Xiumin Li, Yujie Zhang, Huan Ji, Yuqiang Zhao, Zhao Wang, Changyu Mol Genet Genomic Med Original Articles BACKGROUND: Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. METHODS: A total of 381 patients with coronary heart disease were recruited. Based on complete cardiac examination, the patients were divided into two subgroups: 185 patients with AF and 196 patients without AF. An association analysis was performed using 13 genotyped SNPs. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by conditional logistic regression. RESULTS: In our research, we found that KCNE2 rs8134775 was associated with a decreased AF risk in the allele model (OR = 0.70; 95% CI: 0.50–0.97; p = 0.034). Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19–0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20–4.42; p = 0.012). CONCLUSIONS: Our results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF. John Wiley and Sons Inc. 2019-07-04 /pmc/articles/PMC6687643/ /pubmed/31270966 http://dx.doi.org/10.1002/mgg3.835 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Liu, Xiumin
Li, Yujie
Zhang, Huan
Ji, Yuqiang
Zhao, Zhao
Wang, Changyu
The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
title The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
title_full The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
title_fullStr The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
title_full_unstemmed The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
title_short The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
title_sort research of ion channel‐related gene polymorphisms with atrial fibrillation in the chinese han population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687643/
https://www.ncbi.nlm.nih.gov/pubmed/31270966
http://dx.doi.org/10.1002/mgg3.835
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