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Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects

OBJECTIVE: Sedentary lifestyle increases the risk of type 2 diabetes. The aim of this study was to investigate the impact of different levels of energy turnover (ET; low, medium, and high level of physical activity and the corresponding energy intake) on glucose metabolism at zero energy balance, ca...

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Autores principales: Büsing, Franziska, Hägele, Franziska Anna, Nas, Alessa, Hasler, Mario, Müller, Manfred James, Bosy-Westphal, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687696/
https://www.ncbi.nlm.nih.gov/pubmed/31395858
http://dx.doi.org/10.1038/s41387-019-0089-6
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author Büsing, Franziska
Hägele, Franziska Anna
Nas, Alessa
Hasler, Mario
Müller, Manfred James
Bosy-Westphal, Anja
author_facet Büsing, Franziska
Hägele, Franziska Anna
Nas, Alessa
Hasler, Mario
Müller, Manfred James
Bosy-Westphal, Anja
author_sort Büsing, Franziska
collection PubMed
description OBJECTIVE: Sedentary lifestyle increases the risk of type 2 diabetes. The aim of this study was to investigate the impact of different levels of energy turnover (ET; low, medium, and high level of physical activity and the corresponding energy intake) on glucose metabolism at zero energy balance, caloric restriction, and overfeeding. METHODS: Sixteen healthy individuals (13 men, 3 women, 25.1 ± 3.9 years, BMI 24.0 ± 3.2 kg/m(2)) participated in a randomized crossover intervention under metabolic ward conditions. Subjects passed 3 × 3 intervention days. Three levels of physical activity (PAL: low 1.3, medium 1.6, and high 1.8 achieved by walking at 4 km/h for 0, 3 × 55, or 3 × 110 min) were compared under three levels of energy balance (zero energy balance (EB): 100% of energy requirement (Ereq); caloric restriction (CR): 75% Ereq, and overfeeding (OF): 125% Ereq). Continuous interstitial glucose monitoring, C-peptide excretion, and HOMA–IR, as well as postprandial glucose and insulin were measured. RESULTS: Daylong glycemia and insulin secretion did not increase with higher ET at all conditions of energy balance (EB, CR, and OF), despite a correspondingly higher CHO intake (Δ low vs. high ET: +86 to 135 g of CHO/d). At CR, daylong glycemia (p = 0.02) and insulin secretion (p = 0.04) were even reduced with high compared with low ET. HOMA–IR was impaired with OF and improved with CR, whereas ET had no effect on fasting insulin sensitivity. A higher ET led to lower postprandial glucose and insulin levels under conditions of CR and OF. CONCLUSION: Low-intensity physical activity can significantly improve postprandial glycemic response of healthy individuals, independent of energy balance.
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spelling pubmed-66876962019-08-19 Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects Büsing, Franziska Hägele, Franziska Anna Nas, Alessa Hasler, Mario Müller, Manfred James Bosy-Westphal, Anja Nutr Diabetes Article OBJECTIVE: Sedentary lifestyle increases the risk of type 2 diabetes. The aim of this study was to investigate the impact of different levels of energy turnover (ET; low, medium, and high level of physical activity and the corresponding energy intake) on glucose metabolism at zero energy balance, caloric restriction, and overfeeding. METHODS: Sixteen healthy individuals (13 men, 3 women, 25.1 ± 3.9 years, BMI 24.0 ± 3.2 kg/m(2)) participated in a randomized crossover intervention under metabolic ward conditions. Subjects passed 3 × 3 intervention days. Three levels of physical activity (PAL: low 1.3, medium 1.6, and high 1.8 achieved by walking at 4 km/h for 0, 3 × 55, or 3 × 110 min) were compared under three levels of energy balance (zero energy balance (EB): 100% of energy requirement (Ereq); caloric restriction (CR): 75% Ereq, and overfeeding (OF): 125% Ereq). Continuous interstitial glucose monitoring, C-peptide excretion, and HOMA–IR, as well as postprandial glucose and insulin were measured. RESULTS: Daylong glycemia and insulin secretion did not increase with higher ET at all conditions of energy balance (EB, CR, and OF), despite a correspondingly higher CHO intake (Δ low vs. high ET: +86 to 135 g of CHO/d). At CR, daylong glycemia (p = 0.02) and insulin secretion (p = 0.04) were even reduced with high compared with low ET. HOMA–IR was impaired with OF and improved with CR, whereas ET had no effect on fasting insulin sensitivity. A higher ET led to lower postprandial glucose and insulin levels under conditions of CR and OF. CONCLUSION: Low-intensity physical activity can significantly improve postprandial glycemic response of healthy individuals, independent of energy balance. Nature Publishing Group UK 2019-08-08 /pmc/articles/PMC6687696/ /pubmed/31395858 http://dx.doi.org/10.1038/s41387-019-0089-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Büsing, Franziska
Hägele, Franziska Anna
Nas, Alessa
Hasler, Mario
Müller, Manfred James
Bosy-Westphal, Anja
Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
title Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
title_full Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
title_fullStr Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
title_full_unstemmed Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
title_short Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
title_sort impact of energy turnover on the regulation of glucose homeostasis in healthy subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687696/
https://www.ncbi.nlm.nih.gov/pubmed/31395858
http://dx.doi.org/10.1038/s41387-019-0089-6
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