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Identification of drug-specific public TCR driving severe cutaneous adverse reactions

Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate the T cell receptor (TCR) repertoire by next-generation sequencing. A public...

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Detalles Bibliográficos
Autores principales:	Pan, Ren-You, Chu, Mu-Tzu, Wang, Chuang-Wei, Lee, Yun-Shien, Lemonnier, Francois, Michels, Aaron W., Schutte, Ryan, Ostrov, David A., Chen, Chun-Bing, Phillips, Elizabeth Jane, Mallal, Simon Alexander, Mockenhaupt, Maja, Bellón, Teresa, Tassaneeyakul, Wichittra, White, Katie D., Roujeau, Jean-Claude, Chung, Wen-Hung, Hung, Shuen-Iu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687717/ https://www.ncbi.nlm.nih.gov/pubmed/31395875 http://dx.doi.org/10.1038/s41467-019-11396-2

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