Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin

Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects lead to severe diseases among which is Friedreich’s ataxia caused by impaired expression of frataxin (FXN). Fe-S clusters are biosynthesized on the scaffold protein ISCU, with cysteine desulfurase NFS1 providing s...

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Detalles Bibliográficos
Autores principales: Gervason, Sylvain, Larkem, Djabir, Mansour, Amir Ben, Botzanowski, Thomas, Müller, Christina S., Pecqueur, Ludovic, Le Pavec, Gwenaelle, Delaunay-Moisan, Agnès, Brun, Omar, Agramunt, Jordi, Grandas, Anna, Fontecave, Marc, Schünemann, Volker, Cianférani, Sarah, Sizun, Christina, Tolédano, Michel B., D’Autréaux, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687725/
https://www.ncbi.nlm.nih.gov/pubmed/31395877
http://dx.doi.org/10.1038/s41467-019-11470-9

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