Cargando…

Antidromic Analog Signaling

Analog signaling describes the use of graded voltage changes as signals in the axonal compartment. Analog signaling has been described originally in invertebrates but more recent work has established its presence in the mammalian brain (Alle and Geiger, 2006; Shu et al., 2006). In recent years, many...

Descripción completa

Detalles Bibliográficos
Autor principal: Trigo, Federico F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687872/
https://www.ncbi.nlm.nih.gov/pubmed/31427929
http://dx.doi.org/10.3389/fncel.2019.00354
_version_ 1783442796760268800
author Trigo, Federico F.
author_facet Trigo, Federico F.
author_sort Trigo, Federico F.
collection PubMed
description Analog signaling describes the use of graded voltage changes as signals in the axonal compartment. Analog signaling has been described originally in invertebrates but more recent work has established its presence in the mammalian brain (Alle and Geiger, 2006; Shu et al., 2006). In recent years, many different groups have contributed to the understanding of the physiological significance of analog signaling from a cellular perspective (for a recent review the reader may take a look at the work by Zbili and Debanne, 2019 in this Frontiers in Neuroscience Special Issue). The great majority of the experimental work related to analog signaling, however, concerns the propagation of subthreshold voltage changes from the soma to the axon. Much less attention has been paid to the propagation of subthreshold voltage changes in the opposite direction, from the axon to the soma, or to the propagation of local signals within the axon. In this mini review we will describe these other variants of analog signaling that we call here “antidromic” coupling and “local” coupling.
format Online
Article
Text
id pubmed-6687872
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-66878722019-08-19 Antidromic Analog Signaling Trigo, Federico F. Front Cell Neurosci Neuroscience Analog signaling describes the use of graded voltage changes as signals in the axonal compartment. Analog signaling has been described originally in invertebrates but more recent work has established its presence in the mammalian brain (Alle and Geiger, 2006; Shu et al., 2006). In recent years, many different groups have contributed to the understanding of the physiological significance of analog signaling from a cellular perspective (for a recent review the reader may take a look at the work by Zbili and Debanne, 2019 in this Frontiers in Neuroscience Special Issue). The great majority of the experimental work related to analog signaling, however, concerns the propagation of subthreshold voltage changes from the soma to the axon. Much less attention has been paid to the propagation of subthreshold voltage changes in the opposite direction, from the axon to the soma, or to the propagation of local signals within the axon. In this mini review we will describe these other variants of analog signaling that we call here “antidromic” coupling and “local” coupling. Frontiers Media S.A. 2019-08-02 /pmc/articles/PMC6687872/ /pubmed/31427929 http://dx.doi.org/10.3389/fncel.2019.00354 Text en Copyright © 2019 Trigo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Trigo, Federico F.
Antidromic Analog Signaling
title Antidromic Analog Signaling
title_full Antidromic Analog Signaling
title_fullStr Antidromic Analog Signaling
title_full_unstemmed Antidromic Analog Signaling
title_short Antidromic Analog Signaling
title_sort antidromic analog signaling
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687872/
https://www.ncbi.nlm.nih.gov/pubmed/31427929
http://dx.doi.org/10.3389/fncel.2019.00354
work_keys_str_mv AT trigofedericof antidromicanalogsignaling