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LRRK2 interacts with the vacuolar-type H(+)-ATPase pump a1 subunit to regulate lysosomal function
Lysosomal dysfunction lies at the centre of the cellular mechanisms underlying Parkinson’s disease although the precise underlying mechanisms remain unknown. We investigated the role of leucine-rich repeat kinase 2 (LRRK2) on lysosome biology and the autophagy pathway in primary neurons expressing t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687951/ https://www.ncbi.nlm.nih.gov/pubmed/31039583 http://dx.doi.org/10.1093/hmg/ddz088 |