Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial

In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV...

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Autores principales: Murray, Alastair F, Englund, Janet A, Kuypers, Jane, Tielsch, James M, Katz, Joanne, Khatry, Subarna K, Leclerq, Steven C, Chu, Helen Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688054/
https://www.ncbi.nlm.nih.gov/pubmed/31056697
http://dx.doi.org/10.1093/infdis/jiz212
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author Murray, Alastair F
Englund, Janet A
Kuypers, Jane
Tielsch, James M
Katz, Joanne
Khatry, Subarna K
Leclerq, Steven C
Chu, Helen Y
author_facet Murray, Alastair F
Englund, Janet A
Kuypers, Jane
Tielsch, James M
Katz, Joanne
Khatry, Subarna K
Leclerq, Steven C
Chu, Helen Y
author_sort Murray, Alastair F
collection PubMed
description In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.
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spelling pubmed-66880542019-08-14 Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial Murray, Alastair F Englund, Janet A Kuypers, Jane Tielsch, James M Katz, Joanne Khatry, Subarna K Leclerq, Steven C Chu, Helen Y J Infect Dis Major Articles and Brief Reports In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254. Oxford University Press 2019-09-15 2019-05-06 /pmc/articles/PMC6688054/ /pubmed/31056697 http://dx.doi.org/10.1093/infdis/jiz212 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Murray, Alastair F
Englund, Janet A
Kuypers, Jane
Tielsch, James M
Katz, Joanne
Khatry, Subarna K
Leclerq, Steven C
Chu, Helen Y
Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
title Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
title_full Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
title_fullStr Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
title_full_unstemmed Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
title_short Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
title_sort infant pneumococcal carriage during influenza, rsv, and hmpv respiratory illness within a maternal influenza immunization trial
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688054/
https://www.ncbi.nlm.nih.gov/pubmed/31056697
http://dx.doi.org/10.1093/infdis/jiz212
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