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Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy
We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)–infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reacti...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688057/ https://www.ncbi.nlm.nih.gov/pubmed/31086991 http://dx.doi.org/10.1093/infdis/jiz252 |
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author | Kroeze, Stefanie Wit, Ferdinand W Rossouw, Theresa M Steel, Helen C Kityo, Cissy M Siwale, Margaret Akanmu, Sulaimon Mandaliya, Kishor de Jager, Marleen Ondoa, Pascale Reiss, Peter Rinke de Wit, Tobias F Kootstra, Neeltje Hamers, Raph L |
author_facet | Kroeze, Stefanie Wit, Ferdinand W Rossouw, Theresa M Steel, Helen C Kityo, Cissy M Siwale, Margaret Akanmu, Sulaimon Mandaliya, Kishor de Jager, Marleen Ondoa, Pascale Reiss, Peter Rinke de Wit, Tobias F Kootstra, Neeltje Hamers, Raph L |
author_sort | Kroeze, Stefanie |
collection | PubMed |
description | We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)–infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reactive protein, soluble CD163, and soluble scavenger receptor CD14 were significantly higher during ART than in an HIV-uninfected reference group (n = 90), indicating persistent monocyte/macrophage activation, inflammation, and microbial translocation. Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated soluble CD14. High pre-ART levels of each biomarker strongly predicted residual immune activation during ART. Chemokine (C-C motif) ligand 2, lipopolysaccharide-binding protein, C-reactive protein, and interleukin 6 were differentially expressed between countries. Further research is needed on the clinical implications of residual immune dysregulation. |
format | Online Article Text |
id | pubmed-6688057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66880572019-08-14 Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy Kroeze, Stefanie Wit, Ferdinand W Rossouw, Theresa M Steel, Helen C Kityo, Cissy M Siwale, Margaret Akanmu, Sulaimon Mandaliya, Kishor de Jager, Marleen Ondoa, Pascale Reiss, Peter Rinke de Wit, Tobias F Kootstra, Neeltje Hamers, Raph L J Infect Dis Major Articles and Brief Reports We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)–infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reactive protein, soluble CD163, and soluble scavenger receptor CD14 were significantly higher during ART than in an HIV-uninfected reference group (n = 90), indicating persistent monocyte/macrophage activation, inflammation, and microbial translocation. Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated soluble CD14. High pre-ART levels of each biomarker strongly predicted residual immune activation during ART. Chemokine (C-C motif) ligand 2, lipopolysaccharide-binding protein, C-reactive protein, and interleukin 6 were differentially expressed between countries. Further research is needed on the clinical implications of residual immune dysregulation. Oxford University Press 2019-09-15 2019-05-14 /pmc/articles/PMC6688057/ /pubmed/31086991 http://dx.doi.org/10.1093/infdis/jiz252 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Articles and Brief Reports Kroeze, Stefanie Wit, Ferdinand W Rossouw, Theresa M Steel, Helen C Kityo, Cissy M Siwale, Margaret Akanmu, Sulaimon Mandaliya, Kishor de Jager, Marleen Ondoa, Pascale Reiss, Peter Rinke de Wit, Tobias F Kootstra, Neeltje Hamers, Raph L Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy |
title | Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy |
title_full | Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy |
title_fullStr | Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy |
title_full_unstemmed | Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy |
title_short | Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy |
title_sort | plasma biomarkers of human immunodeficiency virus–related systemic inflammation and immune activation in sub-saharan africa before and during suppressive antiretroviral therapy |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688057/ https://www.ncbi.nlm.nih.gov/pubmed/31086991 http://dx.doi.org/10.1093/infdis/jiz252 |
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