Cargando…

Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target

Elastase B (lasB) is a multifunctional metalloenzyme secreted by the gram-negative pathogen Pseudomonas aeruginosa, and this enzyme orchestrates several physiopathological events during bacteria-host interplays. LasB is considered to be a potential target for the development of an innovative chemoth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galdino, Anna Clara M., Viganor, Lívia, de Castro, Alexandre A., da Cunha, Elaine F. F., Mello, Thaís P., Mattos, Larissa M., Pereira, Marcos D., Hunt, Mary C., O’Shaughnessy, Megan, Howe, Orla, Devereux, Michael, McCann, Malachy, Ramalho, Teodorico C., Branquinha, Marta H., Santos, André L. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688126/ https://www.ncbi.nlm.nih.gov/pubmed/31428062 http://dx.doi.org/10.3389/fmicb.2019.01701

Ejemplares similares

The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients
por: O’Shaughnessy, Megan, et al.
Publicado: (2020)

Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa
por: Galdino, Anna Clara Milesi, et al.
Publicado: (2022)

Silver(I) and Copper(II) 1,10-Phenanthroline-5,6-dione Complexes as Promising Antivirulence Strategy against Leishmania: Focus on Gp63 (Leishmanolysin)
por: Oliveira, Simone S. C., et al.
Publicado: (2023)

In vivo Activity of Copper(II), Manganese(II), and Silver(I) 1,10-Phenanthroline Chelates Against Candida haemulonii Using the Galleria mellonella Model
por: Gandra, Rafael M., et al.
Publicado: (2020)

Design of a gold nanoprobe for the detection of Pseudomonas aeruginosa elastase gene (lasB)
por: Farhangi, Alireza, et al.
Publicado: (2020)

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
por: Camberlein, Virgyl, et al.
Publicado: (2022)

Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models
por: Everett, Martin J., et al.
Publicado: (2023)

The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds
por: Oliveira, Simone S. C., et al.
Publicado: (2023)

In Vivo Activity of Metal Complexes Containing 1,10-Phenanthroline and 3,6,9-Trioxaundecanedioate Ligands against Pseudomonas aeruginosa Infection in Galleria mellonella Larvae
por: O’Shaughnessy, Megan, et al.
Publicado: (2022)

Antibacterial activity of metal–phenanthroline complexes against multidrug-resistant Irish clinical isolates: a whole genome sequencing approach
por: O’Shaughnessy, Megan, et al.
Publicado: (2022)

Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice
por: Zhu, Yajie, et al.
Publicado: (2021)

Higher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients
por: Llanos, Agustina, et al.
Publicado: (2023)

Enzymatic Depilation of Animal Hide: Identification of Elastase (LasB) from Pseudomonas aeruginosa MCM B-327 as a Depilating Protease
por: Pandeeti, Emmanuel Vijay Paul, et al.
Publicado: (2011)

Silver(I) and Copper(II) Complexes of 1,10-Phenanthroline-5,6-Dione Against Phialophora verrucosa: A Focus on the Interaction With Human Macrophages and Galleria mellonella Larvae
por: Granato, Marcela Q., et al.
Publicado: (2021)

1,10-Phenanthroline-5,6-Dione–Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa
por: Granato, Marcela Queiroz, et al.
Publicado: (2017)

Peptidases Are Potential Targets of Copper(II)-1,10-Phenanthroline-5,6-dione Complex, a Promising and Potent New Drug against Trichomonas vaginalis
por: Rigo, Graziela Vargas, et al.
Publicado: (2023)

The Pseudomonas aeruginosa protease LasB directly activates IL-1β
por: Sun, Josh, et al.
Publicado: (2020)

Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors
por: Kaya, Cansu, et al.
Publicado: (2021)

Smallpox Disarmed
Publicado: (1899)

Human Single-Chain Antibodies That Neutralize Elastolytic Activity of Pseudomonas aeruginosa LasB
por: Santajit, Sirijan, et al.
Publicado: (2021)

The Birth of Penicillin and the Disarming of Microbes
por: James, D. Geraint
Publicado: (1971)

Chromosome Segregation: Disarming the Protector
por: Sanyal, Swastika, et al.
Publicado: (2013)

Cholera Disarmed—The Triumph of Genius(?)
por: Leach, R. B.
Publicado: (1892)

Yellow Fever Disarmed and Defied
Publicado: (1898)

1,10-Phenanthroline-5,6-dione ethanol monosolvate
por: Dai, Jing-Wei, et al.
Publicado: (2014)

Insights Into the Mode of Action of the Anti-Candida Activity of 1,10-Phenanthroline and its Metal Chelates
por: McCann, Malachy, et al.
Publicado: (2000)

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
por: Kaya, Cansu, et al.
Publicado: (2022)

Antifungal Potential of Copper(II), Manganese(II) and Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming the Candida haemulonii Complex: Impact on the Planktonic and Biofilm Lifestyles
por: Gandra, Rafael M., et al.
Publicado: (2017)

Vaginal journey disarms newborn intestine
por: Van Epps, Heather L.
Publicado: (2006)

Try to disarm the intruder or kill him!
por: Adamo, Adele, et al.
Publicado: (2012)

Uraemia disarms neutrophils against Candida
por: Wang, Monica
Publicado: (2020)

Effect of Satureja khuzistanica essential oil (SKEO) extract on expression of lasA and lasB genes in Pseudomonas aeruginosa
por: Islamieh, Davoud Iman, et al.
Publicado: (2019)

Acetato(1,10-phenanthroline-5,6-dione)silver(I) trihydrate
por: Onuegbu, Jonathan, et al.
Publicado: (2008)

(E)-6,6′-(Diazene-1,2-diyl)bis(1,10-phenanthrolin-5-ol) trichloromethane disolvate: a superconjugated ligand
por: Ahmed, Muhib, et al.
Publicado: (2019)

SAT1 and glioblastoma multiforme: Disarming the resistance
por: Brett-Morris, Adina, et al.
Publicado: (2015)

Disarming the Ultimate Historical Challenge to Scientific Realism
por: Vickers, Peter
Publicado: (2020)

Platelets—Disarmed guardians in the fight against the plague
por: Assinger, Alice
Publicado: (2020)

A wholesale approach to disarm multiple myeloma
por: Cenci, Simone
Publicado: (2023)

VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells
por: Golovkine, Guillaume, et al.
Publicado: (2014)

Synthesis, characterisation, and solution behaviour of Ag(I) bis(phenanthroline-oxazine) complexes and the evaluation of their biological activity against the pathogenic yeast Candida albicans
por: Evans, Clara, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sh93ik3j4jds574q71b7nl3q8u