Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System

Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this revi...

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Detalles Bibliográficos
Autores principales: Zhou, Chenhao, Tuong, Zewen Kelvin, Frazer, Ian Hector
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688195/
https://www.ncbi.nlm.nih.gov/pubmed/31428574
http://dx.doi.org/10.3389/fonc.2019.00682
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author Zhou, Chenhao
Tuong, Zewen Kelvin
Frazer, Ian Hector
author_facet Zhou, Chenhao
Tuong, Zewen Kelvin
Frazer, Ian Hector
author_sort Zhou, Chenhao
collection PubMed
description Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this review we discuss how hyperproliferation renders epithelial cells less sensitive to immune attack, and impacts upon the efficiency of the local immune system. These observations have significance for the design of therapeutic HPV cancer immunotherapies.
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spelling pubmed-66881952019-08-19 Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System Zhou, Chenhao Tuong, Zewen Kelvin Frazer, Ian Hector Front Oncol Oncology Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this review we discuss how hyperproliferation renders epithelial cells less sensitive to immune attack, and impacts upon the efficiency of the local immune system. These observations have significance for the design of therapeutic HPV cancer immunotherapies. Frontiers Media S.A. 2019-08-02 /pmc/articles/PMC6688195/ /pubmed/31428574 http://dx.doi.org/10.3389/fonc.2019.00682 Text en Copyright © 2019 Zhou, Tuong and Frazer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhou, Chenhao
Tuong, Zewen Kelvin
Frazer, Ian Hector
Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_full Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_fullStr Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_full_unstemmed Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_short Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_sort papillomavirus immune evasion strategies target the infected cell and the local immune system
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688195/
https://www.ncbi.nlm.nih.gov/pubmed/31428574
http://dx.doi.org/10.3389/fonc.2019.00682
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