Cargando…

Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis

OBJECTIVE: We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl(4)) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This occur...

Descripción completa

Detalles Bibliográficos
Autores principales: Pickich, Matthew B., Hargrove, Mark W., Phillips, C. Niles, Healy, James C., Moore, Angelique N., Roberts, Michael D., Martin, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688243/
https://www.ncbi.nlm.nih.gov/pubmed/31399137
http://dx.doi.org/10.1186/s13104-019-4540-5
_version_ 1783442846109401088
author Pickich, Matthew B.
Hargrove, Mark W.
Phillips, C. Niles
Healy, James C.
Moore, Angelique N.
Roberts, Michael D.
Martin, Jeffrey S.
author_facet Pickich, Matthew B.
Hargrove, Mark W.
Phillips, C. Niles
Healy, James C.
Moore, Angelique N.
Roberts, Michael D.
Martin, Jeffrey S.
author_sort Pickich, Matthew B.
collection PubMed
description OBJECTIVE: We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl(4)) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This occurred when curcumin was given during induction of disease (preventative arm; 8-week WD with or without curcumin [8WD + C vs. 8WD]) as well as when given after disease development (treatment arm; 12-week WD with or without curcumin during weeks 9–12 [12WD + C vs. 12WD]). Herein, we sought to extend our findings from that study by determining the effects of curcumin supplementation on cytokine/chemokine expression in serum collected from these same rats. RESULTS: 24 cytokines/chemokines were assayed. IL-2 (+ 80%) and IL-13 (+ 83%) were greater with curcumin supplementation in the prevention arm. IL-2 (+ 192%), IL-13 (+ 87%), IL-17A (+ 81%) and fractalkine (+ 121%) were higher while RANTES was lower (− 22%) with curcumin supplementation in the treatment arm (p < 0.05 for all). RANTES concentrations also correlated significantly with hepatic pathology scores of inflammation (r = 0.417, p = 0.008). Select serum cytokines/chemokines were affected with curcumin supplementation in this female rat model of NASH. Moreover, curcumin’s effect(s) on RANTES and its association with liver disease pathogenesis and progression may warrant further investigation.
format Online
Article
Text
id pubmed-6688243
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-66882432019-08-14 Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis Pickich, Matthew B. Hargrove, Mark W. Phillips, C. Niles Healy, James C. Moore, Angelique N. Roberts, Michael D. Martin, Jeffrey S. BMC Res Notes Research Note OBJECTIVE: We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl(4)) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This occurred when curcumin was given during induction of disease (preventative arm; 8-week WD with or without curcumin [8WD + C vs. 8WD]) as well as when given after disease development (treatment arm; 12-week WD with or without curcumin during weeks 9–12 [12WD + C vs. 12WD]). Herein, we sought to extend our findings from that study by determining the effects of curcumin supplementation on cytokine/chemokine expression in serum collected from these same rats. RESULTS: 24 cytokines/chemokines were assayed. IL-2 (+ 80%) and IL-13 (+ 83%) were greater with curcumin supplementation in the prevention arm. IL-2 (+ 192%), IL-13 (+ 87%), IL-17A (+ 81%) and fractalkine (+ 121%) were higher while RANTES was lower (− 22%) with curcumin supplementation in the treatment arm (p < 0.05 for all). RANTES concentrations also correlated significantly with hepatic pathology scores of inflammation (r = 0.417, p = 0.008). Select serum cytokines/chemokines were affected with curcumin supplementation in this female rat model of NASH. Moreover, curcumin’s effect(s) on RANTES and its association with liver disease pathogenesis and progression may warrant further investigation. BioMed Central 2019-08-09 /pmc/articles/PMC6688243/ /pubmed/31399137 http://dx.doi.org/10.1186/s13104-019-4540-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Pickich, Matthew B.
Hargrove, Mark W.
Phillips, C. Niles
Healy, James C.
Moore, Angelique N.
Roberts, Michael D.
Martin, Jeffrey S.
Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
title Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
title_full Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
title_fullStr Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
title_full_unstemmed Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
title_short Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
title_sort effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688243/
https://www.ncbi.nlm.nih.gov/pubmed/31399137
http://dx.doi.org/10.1186/s13104-019-4540-5
work_keys_str_mv AT pickichmatthewb effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis
AT hargrovemarkw effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis
AT phillipscniles effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis
AT healyjamesc effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis
AT mooreangeliquen effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis
AT robertsmichaeld effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis
AT martinjeffreys effectofcurcuminsupplementationonserumexpressionofselectcytokinesandchemokinesinafemaleratmodelofnonalcoholicsteatohepatitis