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Role of KRAS in regulating normal human airway basal cell differentiation

BACKGROUND: KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistently activated, giving cells a growth advantage resulting in cancer. While a grea...

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Detalles Bibliográficos
Autores principales:	Ogawa, Fumihiro, Walters, Matthew S., Shafquat, Afrah, O’Beirne, Sarah L., Kaner, Robert J., Mezey, Jason G., Zhang, Haijun, Leopold, Philip L., Crystal, Ronald G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688249/ https://www.ncbi.nlm.nih.gov/pubmed/31399087 http://dx.doi.org/10.1186/s12931-019-1129-4

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