Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances i...

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Autores principales: Orth, Michael, Metzger, Philipp, Gerum, Sabine, Mayerle, Julia, Schneider, Günter, Belka, Claus, Schnurr, Maximilian, Lauber, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688256/
https://www.ncbi.nlm.nih.gov/pubmed/31395068
http://dx.doi.org/10.1186/s13014-019-1345-6
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author Orth, Michael
Metzger, Philipp
Gerum, Sabine
Mayerle, Julia
Schneider, Günter
Belka, Claus
Schnurr, Maximilian
Lauber, Kirsten
author_facet Orth, Michael
Metzger, Philipp
Gerum, Sabine
Mayerle, Julia
Schneider, Günter
Belka, Claus
Schnurr, Maximilian
Lauber, Kirsten
author_sort Orth, Michael
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome – with a specific focus on protocols involving radio(chemo)therapeutic approaches.
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spelling pubmed-66882562019-08-14 Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches Orth, Michael Metzger, Philipp Gerum, Sabine Mayerle, Julia Schneider, Günter Belka, Claus Schnurr, Maximilian Lauber, Kirsten Radiat Oncol Review Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome – with a specific focus on protocols involving radio(chemo)therapeutic approaches. BioMed Central 2019-08-08 /pmc/articles/PMC6688256/ /pubmed/31395068 http://dx.doi.org/10.1186/s13014-019-1345-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Orth, Michael
Metzger, Philipp
Gerum, Sabine
Mayerle, Julia
Schneider, Günter
Belka, Claus
Schnurr, Maximilian
Lauber, Kirsten
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
title Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
title_full Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
title_fullStr Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
title_full_unstemmed Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
title_short Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
title_sort pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688256/
https://www.ncbi.nlm.nih.gov/pubmed/31395068
http://dx.doi.org/10.1186/s13014-019-1345-6
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