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TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells

BACKGROUND: Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation. TET1 has been reported to be absent in cancers, and to influence various oncogenes and anti-oncogenes. However the function of TET1 in...

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Detalles Bibliográficos
Autores principales:	Wu, Jian, Li, Hongzhe, Shi, Minmin, Zhu, Youwei, Ma, Yang, Zhong, Yiming, Xiong, Cheng, Chen, Hao, Peng, Chenghong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688318/ https://www.ncbi.nlm.nih.gov/pubmed/31399111 http://dx.doi.org/10.1186/s13046-019-1334-5

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