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Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease
Background: Gait disorders represent one of the most disabling features of Parkinson's disease, which may benefit from rehabilitation. No consistent evidence exists about which gait biomechanical factors can be modified by rehabilitation and which clinical characteristic can predict rehabilitat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688512/ https://www.ncbi.nlm.nih.gov/pubmed/31428039 http://dx.doi.org/10.3389/fneur.2019.00826 |
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author | Serrao, Mariano Chini, Giorgia Caramanico, Guido Bartolo, Michelangelo Castiglia, Stefano Filippo Ranavolo, Alberto Conte, Carmela Venditto, Teresa Coppola, Gianluca di Lorenzo, Cherubino Cardinali, Patrizio Pierelli, Francesco |
author_facet | Serrao, Mariano Chini, Giorgia Caramanico, Guido Bartolo, Michelangelo Castiglia, Stefano Filippo Ranavolo, Alberto Conte, Carmela Venditto, Teresa Coppola, Gianluca di Lorenzo, Cherubino Cardinali, Patrizio Pierelli, Francesco |
author_sort | Serrao, Mariano |
collection | PubMed |
description | Background: Gait disorders represent one of the most disabling features of Parkinson's disease, which may benefit from rehabilitation. No consistent evidence exists about which gait biomechanical factors can be modified by rehabilitation and which clinical characteristic can predict rehabilitation-induced improvements. Objectives: The aims of the study were as follows: (i) to recognize the gait parameters modifiable by a short-term rehabilitation program; (ii) to evaluate the gait parameters that can normalize after rehabilitation; and (iii) to identify clinical variables predicting improvements in gait function after rehabilitation. Methods: Thirty-six patients affected by idiopathic Parkinson's disease in Hoehn-Yahr stage 1–3 and 22 healthy controls were included in the study. Both clinical and instrumental (gait analysis) evaluations were performed before and after a 10-weeks rehabilitation treatment. Time-distance parameters, lower limb joint, and trunk kinematics were measured. Results: At baseline evaluation with matched speed, almost all gait parameters were significantly different between patients and healthy controls. After the 10-weeks rehabilitation, most gait parameters improved, and spatial asymmetry and trunk rotation normalized. Multiple linear regression of gender combined with Unified Parkinson's Disease Rating Scale-III predicted both ΔSpeed and ΔStep length of both sides; gender combined with Unified Parkinson's Disease Rating Scale-II predicted ΔCadence; age combined with Hoehn-Yahr score and disease duration predicted Δtrunk rotation range of motion. Conclusions: Impaired gait parameters are susceptible to improvement by rehabilitation, and younger men with Parkinson's disease who are less severely affected and at early disease stage are more susceptible to improvements in gait function after a 10-weeks rehabilitation program. |
format | Online Article Text |
id | pubmed-6688512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66885122019-08-19 Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease Serrao, Mariano Chini, Giorgia Caramanico, Guido Bartolo, Michelangelo Castiglia, Stefano Filippo Ranavolo, Alberto Conte, Carmela Venditto, Teresa Coppola, Gianluca di Lorenzo, Cherubino Cardinali, Patrizio Pierelli, Francesco Front Neurol Neurology Background: Gait disorders represent one of the most disabling features of Parkinson's disease, which may benefit from rehabilitation. No consistent evidence exists about which gait biomechanical factors can be modified by rehabilitation and which clinical characteristic can predict rehabilitation-induced improvements. Objectives: The aims of the study were as follows: (i) to recognize the gait parameters modifiable by a short-term rehabilitation program; (ii) to evaluate the gait parameters that can normalize after rehabilitation; and (iii) to identify clinical variables predicting improvements in gait function after rehabilitation. Methods: Thirty-six patients affected by idiopathic Parkinson's disease in Hoehn-Yahr stage 1–3 and 22 healthy controls were included in the study. Both clinical and instrumental (gait analysis) evaluations were performed before and after a 10-weeks rehabilitation treatment. Time-distance parameters, lower limb joint, and trunk kinematics were measured. Results: At baseline evaluation with matched speed, almost all gait parameters were significantly different between patients and healthy controls. After the 10-weeks rehabilitation, most gait parameters improved, and spatial asymmetry and trunk rotation normalized. Multiple linear regression of gender combined with Unified Parkinson's Disease Rating Scale-III predicted both ΔSpeed and ΔStep length of both sides; gender combined with Unified Parkinson's Disease Rating Scale-II predicted ΔCadence; age combined with Hoehn-Yahr score and disease duration predicted Δtrunk rotation range of motion. Conclusions: Impaired gait parameters are susceptible to improvement by rehabilitation, and younger men with Parkinson's disease who are less severely affected and at early disease stage are more susceptible to improvements in gait function after a 10-weeks rehabilitation program. Frontiers Media S.A. 2019-08-02 /pmc/articles/PMC6688512/ /pubmed/31428039 http://dx.doi.org/10.3389/fneur.2019.00826 Text en Copyright © 2019 Serrao, Chini, Caramanico, Bartolo, Castiglia, Ranavolo, Conte, Venditto, Coppola, di Lorenzo, Cardinali and Pierelli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Serrao, Mariano Chini, Giorgia Caramanico, Guido Bartolo, Michelangelo Castiglia, Stefano Filippo Ranavolo, Alberto Conte, Carmela Venditto, Teresa Coppola, Gianluca di Lorenzo, Cherubino Cardinali, Patrizio Pierelli, Francesco Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease |
title | Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease |
title_full | Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease |
title_fullStr | Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease |
title_full_unstemmed | Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease |
title_short | Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease |
title_sort | prediction of responsiveness of gait variables to rehabilitation training in parkinson's disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688512/ https://www.ncbi.nlm.nih.gov/pubmed/31428039 http://dx.doi.org/10.3389/fneur.2019.00826 |
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