Early Life Stress, Physiology, and Genetics: A Review

Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and ma...

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Detalles Bibliográficos
Autores principales: Fogelman, Nia, Canli, Turhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Psychology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688564/
https://www.ncbi.nlm.nih.gov/pubmed/31428006
http://dx.doi.org/10.3389/fpsyg.2019.01668
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author Fogelman, Nia
Canli, Turhan
author_facet Fogelman, Nia
Canli, Turhan
author_sort Fogelman, Nia
collection PubMed
description Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS-health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS.
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spelling pubmed-66885642019-08-19 Early Life Stress, Physiology, and Genetics: A Review Fogelman, Nia Canli, Turhan Front Psychol Psychology Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS-health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS. Frontiers Media S.A. 2019-08-02 /pmc/articles/PMC6688564/ /pubmed/31428006 http://dx.doi.org/10.3389/fpsyg.2019.01668 Text en Copyright © 2019 Fogelman and Canli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Fogelman, Nia
Canli, Turhan
Early Life Stress, Physiology, and Genetics: A Review
title Early Life Stress, Physiology, and Genetics: A Review
title_full Early Life Stress, Physiology, and Genetics: A Review
title_fullStr Early Life Stress, Physiology, and Genetics: A Review
title_full_unstemmed Early Life Stress, Physiology, and Genetics: A Review
title_short Early Life Stress, Physiology, and Genetics: A Review
title_sort early life stress, physiology, and genetics: a review
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688564/
https://www.ncbi.nlm.nih.gov/pubmed/31428006
http://dx.doi.org/10.3389/fpsyg.2019.01668
work_keys_str_mv AT fogelmannia earlylifestressphysiologyandgeneticsareview
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