Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7

Endoplasmic reticulum (ER)-associated degradation (ERAD) is a protein quality-control pathway in eukaryotes in which misfolded ER proteins are polyubiquitylated, extracted and ultimately degraded by the proteasome. This process involves ER membrane-embedded ubiquitin E2 and E3 enzymes, as well as a...

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Detalles Bibliográficos
Autores principales: Hann, Zachary S., Metzger, Meredith B., Weissman, Allan M., Lima, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688661/
https://www.ncbi.nlm.nih.gov/pubmed/31397327
http://dx.doi.org/10.1107/S2053230X19009786

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