Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact

Nowadays CHK2 mutation is studied frequently in hereditary breast and ovarian cancer patients in addition to BRCA1/BRCA2. CHK2 is a tumor suppressor gene that encodes a serine/threonine kinase, also involved in pathways such as DNA repair, cell cycle regulation and apoptosis in response to DNA damag...

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Detalles Bibliográficos
Autores principales: Badgujar, Nutan V., Tarapara, Bhoomi V., Shah, Franky D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688789/
https://www.ncbi.nlm.nih.gov/pubmed/31398194
http://dx.doi.org/10.1371/journal.pone.0220711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688789/
https://www.ncbi.nlm.nih.gov/pubmed/31398194
http://dx.doi.org/10.1371/journal.pone.0220711

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