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A gene based approach to test genetic association based on an optimally weighted combination of multiple traits
There is increasing evidence showing that pleiotropy is a widespread phenomenon in complex diseases for which multiple correlated traits are often measured. Joint analysis of multiple traits could increase statistical power by aggregating multiple weak effects. Existing methods for multiple trait as...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688794/ https://www.ncbi.nlm.nih.gov/pubmed/31398229 http://dx.doi.org/10.1371/journal.pone.0220914 |