Cargando…

Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI

This study aimed to develop a cardiorespiratory-resolved 3D magnetic resonance imaging (5D MRI: x-y-z-cardiac-respiratory) approach based on 3D motion tracking for investigating the influence of respiration on cardiac ventricular function. A highly-accelerated 2.5-minute sparse MR protocol was devel...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jing, Wang, Yan, Wen, Zhaoying, Feng, Li, Lima, Ana Paula Santos, Mahadevan, Vaikom S., Bolger, Ann, Saloner, David, Ordovas, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689015/
https://www.ncbi.nlm.nih.gov/pubmed/31399608
http://dx.doi.org/10.1038/s41598-019-47869-z
_version_ 1783442969037111296
author Liu, Jing
Wang, Yan
Wen, Zhaoying
Feng, Li
Lima, Ana Paula Santos
Mahadevan, Vaikom S.
Bolger, Ann
Saloner, David
Ordovas, Karen
author_facet Liu, Jing
Wang, Yan
Wen, Zhaoying
Feng, Li
Lima, Ana Paula Santos
Mahadevan, Vaikom S.
Bolger, Ann
Saloner, David
Ordovas, Karen
author_sort Liu, Jing
collection PubMed
description This study aimed to develop a cardiorespiratory-resolved 3D magnetic resonance imaging (5D MRI: x-y-z-cardiac-respiratory) approach based on 3D motion tracking for investigating the influence of respiration on cardiac ventricular function. A highly-accelerated 2.5-minute sparse MR protocol was developed for a continuous acquisition of cardiac images through multiple cardiac and respiratory cycles. The heart displacement along respiration was extracted using a 3D image deformation algorithm, and this information was used to cluster the acquired data into multiple respiratory phases. The proposed approach was tested in 15 healthy volunteers (7 females). Cardiac function parameters, including the end-systolic volume (ESV), end-diastolic volume (EDV), stroke volume (SV), and ejection fraction (EF), were measured for the left and right ventricle in both end-expiration and end-inspiration. Although with the proposed 5D cardiac MRI, there were no significant differences (p > 0.05, t-test) between end-expiration and end-inspiration measurements of the cardiac function in volunteers, incremental respiratory motion parameters that were derived from 3D motion tracking, such as the depth, expiration and inspiration distribution, correlated (p < 0.05, correlation coefficient, Mann-Whitney) with those volume-based parameters of cardiac function and varied between genders. The obtained initial results suggested that this new approach allows evaluation of cardiac function during specific respiratory phases. Thus, it can enable investigation of effects related to respiratory variability and better assessment of cardiac function for studying respiratory and/or cardiac dysfunction.
format Online
Article
Text
id pubmed-6689015
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-66890152019-08-13 Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI Liu, Jing Wang, Yan Wen, Zhaoying Feng, Li Lima, Ana Paula Santos Mahadevan, Vaikom S. Bolger, Ann Saloner, David Ordovas, Karen Sci Rep Article This study aimed to develop a cardiorespiratory-resolved 3D magnetic resonance imaging (5D MRI: x-y-z-cardiac-respiratory) approach based on 3D motion tracking for investigating the influence of respiration on cardiac ventricular function. A highly-accelerated 2.5-minute sparse MR protocol was developed for a continuous acquisition of cardiac images through multiple cardiac and respiratory cycles. The heart displacement along respiration was extracted using a 3D image deformation algorithm, and this information was used to cluster the acquired data into multiple respiratory phases. The proposed approach was tested in 15 healthy volunteers (7 females). Cardiac function parameters, including the end-systolic volume (ESV), end-diastolic volume (EDV), stroke volume (SV), and ejection fraction (EF), were measured for the left and right ventricle in both end-expiration and end-inspiration. Although with the proposed 5D cardiac MRI, there were no significant differences (p > 0.05, t-test) between end-expiration and end-inspiration measurements of the cardiac function in volunteers, incremental respiratory motion parameters that were derived from 3D motion tracking, such as the depth, expiration and inspiration distribution, correlated (p < 0.05, correlation coefficient, Mann-Whitney) with those volume-based parameters of cardiac function and varied between genders. The obtained initial results suggested that this new approach allows evaluation of cardiac function during specific respiratory phases. Thus, it can enable investigation of effects related to respiratory variability and better assessment of cardiac function for studying respiratory and/or cardiac dysfunction. Nature Publishing Group UK 2019-08-09 /pmc/articles/PMC6689015/ /pubmed/31399608 http://dx.doi.org/10.1038/s41598-019-47869-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Jing
Wang, Yan
Wen, Zhaoying
Feng, Li
Lima, Ana Paula Santos
Mahadevan, Vaikom S.
Bolger, Ann
Saloner, David
Ordovas, Karen
Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI
title Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI
title_full Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI
title_fullStr Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI
title_full_unstemmed Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI
title_short Extending Cardiac Functional Assessment with Respiratory-Resolved 3D Cine MRI
title_sort extending cardiac functional assessment with respiratory-resolved 3d cine mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689015/
https://www.ncbi.nlm.nih.gov/pubmed/31399608
http://dx.doi.org/10.1038/s41598-019-47869-z
work_keys_str_mv AT liujing extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT wangyan extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT wenzhaoying extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT fengli extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT limaanapaulasantos extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT mahadevanvaikoms extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT bolgerann extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT salonerdavid extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri
AT ordovaskaren extendingcardiacfunctionalassessmentwithrespiratoryresolved3dcinemri