A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

Autophagy depends on the E2 enzyme, Atg3, functioning in a conserved E1-E2-E3 trienzyme cascade that catalyzes lipidation of Atg8-family ubiquitin-like proteins (UBLs). Molecular mechanisms underlying Atg8 lipidation remain poorly understood despite association of Atg3, the E1 Atg7, and the composit...

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Detalles Bibliográficos
Autores principales: Zheng, Yumei, Qiu, Yu, Grace, Christy R. R., Liu, Xu, Klionsky, Daniel J., Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689050/
https://www.ncbi.nlm.nih.gov/pubmed/31399562
http://dx.doi.org/10.1038/s41467-019-11435-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689050/
https://www.ncbi.nlm.nih.gov/pubmed/31399562
http://dx.doi.org/10.1038/s41467-019-11435-y

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