Cargando…

A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

Picornaviral IRES elements are essential for initiating the cap-independent viral translation. However, three-dimensional structures of these elements remain elusive. Here, we report a 2.84-Å resolution crystal structure of hepatitis A virus IRES domain V (dV) in complex with a synthetic antibody fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koirala, Deepak, Shao, Yaming, Koldobskaya, Yelena, Fuller, James R., Watkins, Andrew M., Shelke, Sandip A., Pilipenko, Evgeny V., Das, Rhiju, Rice, Phoebe A., Piccirilli, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689051/ https://www.ncbi.nlm.nih.gov/pubmed/31399592 http://dx.doi.org/10.1038/s41467-019-11585-z

Ejemplares similares

A G-Quadruplex-Containing RNA Activates Fluorescence in a GFP-Like Fluorophore
por: Huang, Hao, et al.
Publicado: (2014)

Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif
por: Shelke, Sandip A., et al.
Publicado: (2018)

The 5′-Untranslated Region of Picornaviral Genomes
por: Agol, Vadim I.
Publicado: (1991)

A picornaviral loop-to-loop replication complex
por: Claridge, Jolyon K., et al.
Publicado: (2009)

Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
por: Kerkvliet, Jason, et al.
Publicado: (2010)

MicroRNA Antagonism of the Picornaviral Life Cycle: Alternative Mechanisms of Interference
por: Kelly, Elizabeth J., et al.
Publicado: (2010)

Structures and Corresponding Functions of Five Types of Picornaviral 2A Proteins
por: Yang, Xiaoyao, et al.
Publicado: (2017)

Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells
por: Sun, Di, et al.
Publicado: (2016)

Affinity maturation of a portable Fab–RNA module for chaperone-assisted RNA crystallography
por: Koirala, Deepak, et al.
Publicado: (2018)

Synthesizing topological structures containing RNA
por: Liu, Di, et al.
Publicado: (2017)

Deconstructing internal ribosome entry site elements: an update of structural motifs and functional divergences
por: Lozano, Gloria, et al.
Publicado: (2018)

Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein
por: Banerjee, Sravani, et al.
Publicado: (2018)

Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development
por: Li, Zengbin, et al.
Publicado: (2019)

NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII
por: Aumayr, Martina, et al.
Publicado: (2015)

The SARS-CoV-2 Programmed −1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography
por: Roman, Christina, et al.
Publicado: (2021)

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination
por: Koldobskaya, Yelena, et al.
Publicado: (2010)

Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients
por: Ko, Kichul, et al.
Publicado: (2013)

Exploring Internal Ribosome Entry Sites as Therapeutic Targets
por: Komar, Anton A., et al.
Publicado: (2015)

Computationally-guided design and selection of high performing ribosomal active site mutants
por: Kofman, Camila, et al.
Publicado: (2022)

Structural basis for topological regulation of Tn3 resolvase
por: Montaño, Sherwin P, et al.
Publicado: (2022)

Crystal Structure of the VS ribozyme
por: Suslov, Nikolai B., et al.
Publicado: (2015)

The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes
por: DasGupta, Saurja, et al.
Publicado: (2021)

Downstream Ribosomal Entry for Translation of Coronavirus TGEV Gene 3b
por: O'Connor, Jennifer Black, et al.
Publicado: (2000)

Finding 3D motifs in ribosomal RNA structures
por: Apostolico, Alberto, et al.
Publicado: (2009)

Arrangement of 3D structural motifs in ribosomal RNA
por: Sargsyan, Karen, et al.
Publicado: (2010)

Crystal structure of a cap-independent translation enhancer RNA
por: Lewicka, Anna, et al.
Publicado: (2023)

Community science designed ribosomes with beneficial phenotypes
por: Krüger, Antje, et al.
Publicado: (2023)

IRESpy: an XGBoost model for prediction of internal ribosome entry sites
por: Wang, Junhui, et al.
Publicado: (2019)

Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis
por: Mountford, Peter S., et al.
Publicado: (1995)

Regulating amyloid precursor protein synthesis through an internal ribosomal entry site
por: Beaudoin, Monique E., et al.
Publicado: (2008)

Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal
por: Fuller, James R, et al.
Publicado: (2017)

Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
por: Gritsenko, Alexey A., et al.
Publicado: (2017)

Cellular automata simulation of topological effects on the dynamics of feed-forward motifs
por: Apte, Advait A, et al.
Publicado: (2008)

Analysis of interactions between ribosomal proteins and RNA structural motifs
por: Ciriello, Giovanni, et al.
Publicado: (2010)

RNA regulons in Hox 5′UTRs confer ribosome specificity to gene regulation
por: Xue, Shifeng, et al.
Publicado: (2014)

Structural changes of an abasic site in duplex DNA affect noncovalent binding of the spin label ç
por: Shelke, Sandip A., et al.
Publicado: (2012)

Membrane-bound ribosomes of myeloma cells. II. Kinetic studies on the entry of newly made ribosomal subunits into the free and the membrane- bound ribosomal particles
Publicado: (1975)

A gastrin transcript expressed in gastrointestinal cancer cells contains an internal ribosome entry site
por: Grabowska, A M, et al.
Publicado: (2008)

A search for structurally similar cellular internal ribosome entry sites
por: Baird, Stephen D., et al.
Publicado: (2007)

Common sequence motifs of nascent chains engage the ribosome surface and trigger factor
por: Deckert, Annika, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jvtmc90rp0pgjd9e8r2ain2nrn