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Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice

Senescence is a mechanism associated with aging that alters tissue regeneration by depleting the stem cell pool. Chronic obstructive pulmonary disease (COPD) displays hallmarks of senescence, including a diminished stem cell population. DNA damage from cigarette smoke (CS) induces senescence via the...

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Detalles Bibliográficos
Autores principales:	Cottage, Christopher T., Peterson, Norman, Kearley, Jennifer, Berlin, Aaron, Xiong, Ximing, Huntley, Anna, Zhao, Weiguang, Brown, Charles, Migneault, Annik, Zerrouki, Kamelia, Criner, Gerald, Kolbeck, Roland, Connor, Jane, Lemaire, Raphael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689060/ https://www.ncbi.nlm.nih.gov/pubmed/31428695 http://dx.doi.org/10.1038/s42003-019-0532-1

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