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Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction

Porcine protegrin-1 (PG-1) is a broad-spectrum antimicrobial peptide (AMP) with potent antimicrobial activities. We produced recombinant PG-1 and evaluated its cytotoxicity toward various types of mammalian cell lines, including embryonic fibroblasts, retinal cells, embryonic kidney cells, neuroblas...

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Detalles Bibliográficos
Autores principales:	Soundrarajan, Nagasundarapandian, Park, Suhyun, Le Van Chanh, Quy, Cho, Hye-sun, Raghunathan, Govindan, Ahn, Byeongyong, Song, Hyuk, Kim, Jin-Hoi, Park, Chankyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689069/ https://www.ncbi.nlm.nih.gov/pubmed/31399625 http://dx.doi.org/10.1038/s41598-019-47955-2

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