Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated with poor survival in different cancer types, and transgenic overexpression of hepsin leads t...

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Detalles Bibliográficos
Autores principales: Willbold, Ramona, Wirth, Katharina, Martini, Thomas, Sültmann, Holger, Bolenz, Christian, Wittig, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689070/
https://www.ncbi.nlm.nih.gov/pubmed/31399560
http://dx.doi.org/10.1038/s41419-019-1830-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689070/
https://www.ncbi.nlm.nih.gov/pubmed/31399560
http://dx.doi.org/10.1038/s41419-019-1830-8

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