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Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we analyze chromatin accessibility, active regulatory elements marked by H3K27ac, and DNA methylation at 42 risk...

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Detalles Bibliográficos
Autores principales:	Speedy, Helen E., Beekman, Renée, Chapaprieta, Vicente, Orlando, Giulia, Law, Philip J., Martín-García, David, Gutiérrez-Abril, Jesús, Catovsky, Daniel, Beà, Sílvia, Clot, Guillem, Puiggròs, Montserrat, Torrents, David, Puente, Xose S., Allan, James M., López-Otín, Carlos, Campo, Elias, Houlston, Richard S., Martín-Subero, José I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689100/ https://www.ncbi.nlm.nih.gov/pubmed/31399598 http://dx.doi.org/10.1038/s41467-019-11582-2

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