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MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer

Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR-382 has been observed in various types of cancers. However, the biological function of miR-382 in colorectal cancer (CRC) is still largely unknown. Here, we found that miR-382 was...

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Autores principales: Yao, Hui, Xia, Dong, Li, Zong-lin, Ren, Lei, Wang, Ming-ming, Chen, Wang-sheng, Hu, Zheng-chuan, Yi, Guo-ping, Xu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689104/
https://www.ncbi.nlm.nih.gov/pubmed/29700213
http://dx.doi.org/10.1042/BSR20180441
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author Yao, Hui
Xia, Dong
Li, Zong-lin
Ren, Lei
Wang, Ming-ming
Chen, Wang-sheng
Hu, Zheng-chuan
Yi, Guo-ping
Xu, Liang
author_facet Yao, Hui
Xia, Dong
Li, Zong-lin
Ren, Lei
Wang, Ming-ming
Chen, Wang-sheng
Hu, Zheng-chuan
Yi, Guo-ping
Xu, Liang
author_sort Yao, Hui
collection PubMed
description Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR-382 has been observed in various types of cancers. However, the biological function of miR-382 in colorectal cancer (CRC) is still largely unknown. Here, we found that miR-382 was down-regulated in human colorectal cancer tissues and cell lines associated with it. MiR-382 inhibited colorectal cancer cell proliferation, migration, invasion, and enhance chemosensitivity. Furthermore, we identified Krüppel-like factor 12 (KLF12) and homeodomain-interacting protein kinase 3 (HIPK3) as the target of miR-382, and miR-382 rescued the promotion effect of KFL12 on migration and enhanced chemosensitivity in colorectal cancer cell lines. Collectively, these findings revealed that miR-382 inhibits migration and enhances chemosensitivity by targeting KLF12 and HIPK3 in colorectal cancer. These findings might serve as a tumor suppressor in CRC.
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spelling pubmed-66891042019-08-23 MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer Yao, Hui Xia, Dong Li, Zong-lin Ren, Lei Wang, Ming-ming Chen, Wang-sheng Hu, Zheng-chuan Yi, Guo-ping Xu, Liang Biosci Rep Research Articles Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR-382 has been observed in various types of cancers. However, the biological function of miR-382 in colorectal cancer (CRC) is still largely unknown. Here, we found that miR-382 was down-regulated in human colorectal cancer tissues and cell lines associated with it. MiR-382 inhibited colorectal cancer cell proliferation, migration, invasion, and enhance chemosensitivity. Furthermore, we identified Krüppel-like factor 12 (KLF12) and homeodomain-interacting protein kinase 3 (HIPK3) as the target of miR-382, and miR-382 rescued the promotion effect of KFL12 on migration and enhanced chemosensitivity in colorectal cancer cell lines. Collectively, these findings revealed that miR-382 inhibits migration and enhances chemosensitivity by targeting KLF12 and HIPK3 in colorectal cancer. These findings might serve as a tumor suppressor in CRC. Portland Press Ltd. 2019-08-09 /pmc/articles/PMC6689104/ /pubmed/29700213 http://dx.doi.org/10.1042/BSR20180441 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Yao, Hui
Xia, Dong
Li, Zong-lin
Ren, Lei
Wang, Ming-ming
Chen, Wang-sheng
Hu, Zheng-chuan
Yi, Guo-ping
Xu, Liang
MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
title MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
title_full MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
title_fullStr MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
title_full_unstemmed MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
title_short MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
title_sort mir-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689104/
https://www.ncbi.nlm.nih.gov/pubmed/29700213
http://dx.doi.org/10.1042/BSR20180441
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