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Role of stem cells in fertility preservation: current insights

While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm...

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Autores principales: Vermeulen, Maxime, Giudice, Maria-Grazia, Del Vento, Federico, Wyns, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689135/
https://www.ncbi.nlm.nih.gov/pubmed/31496751
http://dx.doi.org/10.2147/SCCAA.S178490
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author Vermeulen, Maxime
Giudice, Maria-Grazia
Del Vento, Federico
Wyns, Christine
author_facet Vermeulen, Maxime
Giudice, Maria-Grazia
Del Vento, Federico
Wyns, Christine
author_sort Vermeulen, Maxime
collection PubMed
description While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of healthy babies after autotransplantation and is performed in an increasing number of centers. For prepubertal boys who do not produce gametes ready for fertilization, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells may be proposed as an experimental strategy with the aim of restoring fertility. Based on achievements in nonhuman primates, autotransplantation of ITT or testicular cell suspensions appears promising to restore fertility of young cancer survivors. So far, whether in two- or three-dimensional culture systems, in vitro maturation of immature male and female gonadal cells or tissue has not demonstrated a capacity to produce safe gametes for ART. Recently, primordial germ cells have been generated from embryonic and induced pluripotent stem cells, but further investigations regarding efficiency and safety are needed. Transplantation of mesenchymal stem cells to improve the vascularization of gonadal tissue grafts, increase the colonization of transplanted cells, and restore the damaged somatic compartment could overcome the current limitations encountered with transplantation.
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spelling pubmed-66891352019-09-06 Role of stem cells in fertility preservation: current insights Vermeulen, Maxime Giudice, Maria-Grazia Del Vento, Federico Wyns, Christine Stem Cells Cloning Review While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of healthy babies after autotransplantation and is performed in an increasing number of centers. For prepubertal boys who do not produce gametes ready for fertilization, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells may be proposed as an experimental strategy with the aim of restoring fertility. Based on achievements in nonhuman primates, autotransplantation of ITT or testicular cell suspensions appears promising to restore fertility of young cancer survivors. So far, whether in two- or three-dimensional culture systems, in vitro maturation of immature male and female gonadal cells or tissue has not demonstrated a capacity to produce safe gametes for ART. Recently, primordial germ cells have been generated from embryonic and induced pluripotent stem cells, but further investigations regarding efficiency and safety are needed. Transplantation of mesenchymal stem cells to improve the vascularization of gonadal tissue grafts, increase the colonization of transplanted cells, and restore the damaged somatic compartment could overcome the current limitations encountered with transplantation. Dove 2019-08-05 /pmc/articles/PMC6689135/ /pubmed/31496751 http://dx.doi.org/10.2147/SCCAA.S178490 Text en © 2019 Vermeulen et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Vermeulen, Maxime
Giudice, Maria-Grazia
Del Vento, Federico
Wyns, Christine
Role of stem cells in fertility preservation: current insights
title Role of stem cells in fertility preservation: current insights
title_full Role of stem cells in fertility preservation: current insights
title_fullStr Role of stem cells in fertility preservation: current insights
title_full_unstemmed Role of stem cells in fertility preservation: current insights
title_short Role of stem cells in fertility preservation: current insights
title_sort role of stem cells in fertility preservation: current insights
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689135/
https://www.ncbi.nlm.nih.gov/pubmed/31496751
http://dx.doi.org/10.2147/SCCAA.S178490
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