Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproduct...

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Autores principales: Cao, Yubin, Li, Zeping, Jiang, Wenyu, Ling, Yan, Kuang, Haibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689161/
https://www.ncbi.nlm.nih.gov/pubmed/31399145
http://dx.doi.org/10.1186/s12958-019-0511-x
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author Cao, Yubin
Li, Zeping
Jiang, Wenyu
Ling, Yan
Kuang, Haibin
author_facet Cao, Yubin
Li, Zeping
Jiang, Wenyu
Ling, Yan
Kuang, Haibin
author_sort Cao, Yubin
collection PubMed
description Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.
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spelling pubmed-66891612019-08-15 Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery Cao, Yubin Li, Zeping Jiang, Wenyu Ling, Yan Kuang, Haibin Reprod Biol Endocrinol Review Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases. BioMed Central 2019-08-09 /pmc/articles/PMC6689161/ /pubmed/31399145 http://dx.doi.org/10.1186/s12958-019-0511-x Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Cao, Yubin
Li, Zeping
Jiang, Wenyu
Ling, Yan
Kuang, Haibin
Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
title Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
title_full Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
title_fullStr Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
title_full_unstemmed Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
title_short Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
title_sort reproductive functions of kisspeptin/kiss1r systems in the periphery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689161/
https://www.ncbi.nlm.nih.gov/pubmed/31399145
http://dx.doi.org/10.1186/s12958-019-0511-x
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