Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis

The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression...

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Detalles Bibliográficos
Autores principales: Hoepner, Robert, Bagnoud, Maud, Pistor, Maximilian, Salmen, Anke, Briner, Myriam, Synn, Helen, Schrewe, Lisa, Guse, Kirsten, Ahmadi, Farhad, Demir, Seray, Laverick, Louis, Gresle, Melissa, Worley, Paul, Reichardt, Holger Michael, Butzkueven, Helmut, Gold, Ralf, Metz, Imke, Lühder, Fred, Chan, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689294/
https://www.ncbi.nlm.nih.gov/pubmed/31030237
http://dx.doi.org/10.1007/s00401-019-02018-8

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