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Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro α-glucosidase inhibition

PURPOSE: We aimed to enhance the solubility, dissolution rate, oral bioavailability, and α-glucosidase inhibition of glimepiride (Glm) by fabricating its nanosuspension using a precipitation–ultrasonication approach. METHODS: Glm nanosuspensions were fabricated using optimized processing conditions....

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Detalles Bibliográficos
Autores principales:	Rahim, Haroon, Sadiq, Abdul, Khan, Shahzeb, Amin, Fazli, Ullah, Riaz, Shahat, Abdelaaty A, Mahmood, Hafiz Majid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689535/ https://www.ncbi.nlm.nih.gov/pubmed/31496686 http://dx.doi.org/10.2147/IJN.S210548

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