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Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice

PURPOSE: Mn-doped ZnS quantum dots (QDs) with special luminescent properties have been widely researched and applied in various fields. Thus, their release toxicity and security cannot be ignored. METHODS: In the present study, the toxicity and non-targeted metabolomics of Mn-doped ZnS QDs were inve...

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Autores principales: Yang, Yanjie, Lv, Shuangyu, Wang, Fengling, An, Yang, Fang, Na, Zhang, Weijuan, Zhao, Wei, Guo, Xiangqian, Ji, Shaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689551/
https://www.ncbi.nlm.nih.gov/pubmed/31496687
http://dx.doi.org/10.2147/IJN.S212355
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author Yang, Yanjie
Lv, Shuangyu
Wang, Fengling
An, Yang
Fang, Na
Zhang, Weijuan
Zhao, Wei
Guo, Xiangqian
Ji, Shaoping
author_facet Yang, Yanjie
Lv, Shuangyu
Wang, Fengling
An, Yang
Fang, Na
Zhang, Weijuan
Zhao, Wei
Guo, Xiangqian
Ji, Shaoping
author_sort Yang, Yanjie
collection PubMed
description PURPOSE: Mn-doped ZnS quantum dots (QDs) with special luminescent properties have been widely researched and applied in various fields. Thus, their release toxicity and security cannot be ignored. METHODS: In the present study, the toxicity and non-targeted metabolomics of Mn-doped ZnS QDs were investigated after single intravenous injection. Serum metabolites were evaluated based on gas chromatography–mass spectrometry together with multivariate statistical analyses [principal component analysis, partial least squares discriminant analysis, and orthogonal PLS-DA]. RESULTS: The modified metabolites (variable importance in the projection (VIP) >1 and p<0.05) revealed that Mn-doped ZnS QDs exposure disturbed glycolysis, tricarboxylic acid cycle, ketoplasia, glutaminolysis, and amino acid and lipid metabolism. The behavior, coefficients of organs, and histological changes were the same as in the control group, and the disturbance of hematology and serum biochemistry was not dose- or time-dependent. CONCLUSION: Our study provides a general observation regarding the toxicity and potential metabolic responses of mice exposed to Mn-doped ZnS QDs.
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spelling pubmed-66895512019-09-06 Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice Yang, Yanjie Lv, Shuangyu Wang, Fengling An, Yang Fang, Na Zhang, Weijuan Zhao, Wei Guo, Xiangqian Ji, Shaoping Int J Nanomedicine Original Research PURPOSE: Mn-doped ZnS quantum dots (QDs) with special luminescent properties have been widely researched and applied in various fields. Thus, their release toxicity and security cannot be ignored. METHODS: In the present study, the toxicity and non-targeted metabolomics of Mn-doped ZnS QDs were investigated after single intravenous injection. Serum metabolites were evaluated based on gas chromatography–mass spectrometry together with multivariate statistical analyses [principal component analysis, partial least squares discriminant analysis, and orthogonal PLS-DA]. RESULTS: The modified metabolites (variable importance in the projection (VIP) >1 and p<0.05) revealed that Mn-doped ZnS QDs exposure disturbed glycolysis, tricarboxylic acid cycle, ketoplasia, glutaminolysis, and amino acid and lipid metabolism. The behavior, coefficients of organs, and histological changes were the same as in the control group, and the disturbance of hematology and serum biochemistry was not dose- or time-dependent. CONCLUSION: Our study provides a general observation regarding the toxicity and potential metabolic responses of mice exposed to Mn-doped ZnS QDs. Dove 2019-08-06 /pmc/articles/PMC6689551/ /pubmed/31496687 http://dx.doi.org/10.2147/IJN.S212355 Text en © 2019 Yang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Yang, Yanjie
Lv, Shuangyu
Wang, Fengling
An, Yang
Fang, Na
Zhang, Weijuan
Zhao, Wei
Guo, Xiangqian
Ji, Shaoping
Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_full Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_fullStr Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_full_unstemmed Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_short Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_sort toxicity and serum metabolomics investigation of mn-doped zns quantum dots in mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689551/
https://www.ncbi.nlm.nih.gov/pubmed/31496687
http://dx.doi.org/10.2147/IJN.S212355
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